Senior Scientist I - Drug Metabolism

About the role

The Senior Scientist I will design and conduct absorption, distribution, metabolism and excretion (ADME) research on compounds, drug agents and metabolites in pre-clinical and/or clinical development. Uses a physicochemical approach, attempting to compile various data such as absorption and excretion rates and drug agent half-life in order to establish pharmacokinetic profiles of new chemical and/or molecular entities as well as determining the optimum and safe dosage forms for compounds that have been determined to have indications for various disease groups. Develops protocols and/or prepares study documentation and findings to support domestic and international submissions of new drugs.

Responsibilities

• Lead DMPK strategy for discovery programs across multiple therapeutic areas, aligning ADME objectives with project milestones.
• Design and interpret in vitro and in vivo ADME studies to inform lead optimization and candidate selection.
• Apply fit-for-purpose in silico models, PK/PD, PBPK, exposure–response, to predict human pharmacokinetics/dose and de-risk programs.
• Integrate DMPK data with medicinal chemistry and pharmacology to guide chemical design and prioritize novel chemical matter with favorable drug like properties.
• Propose and oversee internal and external research initiatives, including study design, data analysis, and documentation to meet project goals.
• Collaborate with outsourcing managers to identify, qualify and manage CRO partners with specialized ADME capabilities; ensure quality, timelines and cost effectiveness.
• Engage and collaborate with global Novo Nordisk ADME experts to harmonize methodologies, share best practices and leverage cross-site expertise.
• Provide scientific mentorship and technical leadership to DMPK team members and cross-functional colleagues.
• Communicate DMPK strategy, findings and risk assessments clearly to project teams and senior management; contribute to go/no go decisions.
• Represent the company externally as needed (publications, conferences, scientific consortia) to build visibility for DMPK methods and capabilities.
• Maintain awareness of emerging DMPK methodologies, regulatory expectations and modeling technologies; implement applicable innovations to improve discovery throughput and predictivity.

Requirements

• BS/BA with 10+ years of relevant experience; or master’s degree with 8+ years of relevant experience; or PhD with 4+ years’ of relevant experience required.
• Experience in designing and conducting absorption, distribution, metabolism, and excretion (ADME) research in a pre-clinical and/or clinical development setting.
• Excellent understanding of ADME principals with hands-on experience with PK and PK/PD modeling or biotransformation highly desirable.
• Strong knowledge and experience in pharmacokinetics and drug metabolism.
• Preferred experience includes: DMPK or PK/PD modeling project representative.
• Proficiency in scientific communication and stakeholder engagement.

Qualifications

• BS/BA with 10+ years of relevant experience; or master’s degree with 8+ years of relevant experience; or PhD with 4+ years’ of relevant experience required.
• Experience in designing and conducting absorption, distribution, metabolism, and excretion (ADME) research in a pre-clinical and/or clinical development setting.
• Excellent understanding of ADME principals with hands-on experience with PK and PK/PD modeling or biotransformation highly desirable.
• Strong knowledge and experience in pharmacokinetics and drug metabolism.
• Preferred experience includes: DMPK or PK/PD modeling project representative.
• Proficiency in scientific communication and stakeholder engagement.

Benefits

• Base compensation range for this position is $140,000 to $190,000.
• The position is also eligible for a company bonus based on individual and company performance.
• Novo Nordisk offers long-term incentive compensation and/or company vehicles depending on the position's level or other company factors.
• Employees are also eligible to participate in Company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance.
• The Company also offers time off pursuant to its sick time policy, flexible vacation policy, and parental leave policy.

Pay

• The base compensation range for this position is $140,000 to $190,000.

Schedule

• Full time.