Scientist/Senior Scientist for Pharmacology

Key Responsibilities

• In Vivo Pharmacology: Design and develop animal models, execute in vivo experiments, lead service projects, and act as Project Manager or Study Director.
• Animal Handling: Perform tasks such as animal handling, tumor inoculation, drug administration, blood and tissue collection, tumor measurements, and PK/PD studies.
• Model Building: Independently lead internal model-building projects and characterize humanized mouse models.
• Technical Support: Provide troubleshooting support and technical guidance to junior associates.
• Collaboration: Collaborate with the BD/Sales team for client project planning and technical discussions.
• Client Presentation: Present project results to clients and internal stakeholders; prepare scientific reports and summaries.
• Mentorship: Mentor and facilitate the growth of junior research associates.

In Vitro and Ex Vivo Pharmacology

• Immune Cell Profiling: Develop and validate assays including immune cell profiling from blood and tissues.
• Functional Assays: Conduct functional assays using primary cells like T cells, NK cells, and macrophages.
• Cytokine Profiling: Perform cytokine profiling, cytotoxicity, and apoptosis assays.
• New Assay Development: Develop new assay technologies by researching scientific literature and adapting methodologies.
• Flow Cytometry: Execute flow cytometry (FACS), ELISA, Western blot, qRT-PCR, and multiplex cytokine analyses.
• Support In Vivo Studies: Contribute to in vivo pharmacology studies from an in vitro perspective.
• Scientific Presentations: Present research findings at internal meetings and contribute to external scientific discussions.

Requirements

• PhD in pharmacology, immunology, cancer biology, or related biomedical field.
• Extensive hands-on experience in animal models and preclinical in vivo pharmacology.
• Proven skills in cell-based immunological assays including T cell activation, NK cell-mediated cytotoxicity, and macrophage functional assays.
• Expertise in PK/PD model establishment and analysis.
• Proficiency in flow cytometry, cytokine profiling (ELISA, qRT-PCR, multiplex assays), and immune cell isolation from tissues.
• Experience with surgical procedures in rodents is highly desirable.
• Cross-functional knowledge across therapeutic areas is a plus.
• Strong communication, organizational, and team collaboration skills with the ability to prioritize in a fast-paced environment.
• Demonstrated ability to independently manage projects and work with cross-functional teams.

Benefits

• Medical Insurance
• Dental Insurance
• Vision Insurance
• Health Reimbursement Accounts
• Life and AD&D Insurance
• Short & Long Term Disability Insurance
• 401K with Company Match
• Paid Time Off
• Paid Sick Days & Holidays

About the Role

Biocytogen Boston Corp is seeking a highly motivated and versatile Pharmacology Scientist to support both in vivo and in vitro preclinical research services in the fields of immunology, immuno-oncology, metabolic disease and neurology.