Senior Scientist / Scientist, In Vivo Pharmacology

Back to jobs New Senior Scientist / Scientist, In Vivo Pharmacology South San Francisco Company info NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Description NewLimit is seeking a talented Scientist / Senior Scientist of In Vivo Pharmacology to join our Translational Sciences team. This critical role designs and executes in vivo studies to evaluate pioneering epigenetic reprogramming therapeutics across our entire portfolio. As a subject matter expert in nonclinical and PK/PD study design, you will lead in vivo pharmacology strategies, collaborate cross-functionally with therapeutic area teams, and directly drive therapeutic candidate selection. As a Senior Scientist/Scientist On Our Team, You Will Design, execute, and interpret in vivo pharmacology studies (PK/PD, efficacy, dose-response) across multiple disease models and therapeutic programsCollaborate with Epigenetic Editing, Predictive Modeling, and other therapeutic area teams to evaluate epigenetic reprogramming payloads in relevant animal modelsDevelop and refine animal models of aging and age-related disease to support translational studiesOversee study design, protocol development, and CRO/vendor relationships for in vivo studiesAnalyze and interpret in vivo data (PK/PD, biomarkers, functional endpoints) to drive pre-clinical decision makingContribute to regulatory-enabling study design and documentation as programs progress toward clinical Requirements Ph.D. in pharmacology, physiology, biology or a related field or equivalent industry experience (5+ years for Scientist; 8+ years for Senior Scientist)Demonstrated experience designing and executing in vivo pharmacology studies (PK, PD, efficacy, dose-range finding) in rodent modelsExperience with study design, dosing regimens, and route-of-administration selectionExperience analyzing and interpreting in vivo pharmacology data to inform program decisionsExperience leading project workflows and providing technical mentorship to junior laboratory staffHistory of contributing to a drug development program at the pre-clinical or clinical development stage Nice to have Experience with liver biology, hepatic disease models, or hepatocyte-directed deliveryExperience with nucleic acid or viral vector delivery in vivoExperience with GLP-enabling or IND-enabling study designExperience with single cell genomics or pooled screening approaches applied to in vivo readouts Benefits NewLimit offers generous benefits to ensure our team can focus on our mission: Health, dental, and vision insurance401(k) with company matchPaid parental leaveIndustry-leading paid time off (PTO) — 20 days/year for all employees + holidaysMeals and snacks on-site Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future. Create a Job Alert Interested in building your career at NewLimit? Get future opportunities sent straight to your email. Apply for this job indicates a required field First Name* Last Name* Email* Phone Country Phone Resume/CV Attach Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website