Senior Scientist, Pharmacology

Janux Therapeutics is seeking a scientifically curious and motivated Senior Scientist with demonstrated abilities to work in a fast-paced environment. The incumbent will design, develop, and execute in vitro assays for compound characterization using multicolor flow cytometry, cell-based functional assays, MSD, Octet, and other relevant technologies, as well as develop murine models for efficacy evaluation and mechanism-of-action (MoA) investigations.

About the role

This position is hands-on and requires strong experimental execution, data interpretation, communication, CRO management, and documentation of results that enable the advancement of novel research molecules toward development candidates. As a strategic team member, you will directly support decision-making for pipeline programs as they progress from early Research through IND-enabling studies, IND submission, and clinical development. This position will report directly to the Senior Director of Pharmacology.

Responsibilities

• Identify, develop, and execute multicolor flow cytometry panels, in vitro functional assays, and in vivo pharmacology studies independently to support both in vivo and in vitro pharmacology programs.
• Independently design and execute assays, including assay development, optimization, qualification (when required), sample analysis, data analysis, and preparation of study reports and SOPs.
• Develop and implement murine models to support target and MoA validation.
• Analyze and present experimental data using Prism, Excel, MS Office, or similar software, and present findings to cross-functional groups.
• Maintain detailed records of studies in electronic lab notebooks (ELNs).
• Keep up to date with published literature related to therapeutic targets, disease biology, and mechanisms relevant to Janux programs.
• Train and support junior team members to design, manage, and execute complex experimental studies.
• Produce detailed documentation of experiments within a lab notebook and electronically.
• Collaborate effectively with cross-functional teams and external CROs to ensure successful study execution and delivery of project milestones.
• Schedule and prioritize workload effectively within a multi-task environment.
• Perform other duties as deemed necessary.

Requirements

• Ph.D. in Immunology, Cell Biology, Biotechnology, Pharmacology, or a related discipline with at least 3 years of drug discovery experience, MS + 10 years of drug discovery experience, or BS + 12 years of drug discovery experience in an industry setting is required.
• Strong expertise and hands-on experience with multicolor flow cytometry panel development and cell-based functional assays.
• Experience with assay qualification and validation, including flow cytometry panels and bioanalytical assays (PK, ADA, and Nab), is preferred.
• Strong understanding and prior experience working in oncology, immunology, and immune-oncology, with hands-on experience in murine model development and associated sample analysis.
• Experience working with external CROs (due diligence, oversight, project management, data review, and reporting) is desirable.
• Competence in data analysis tools (Excel, GraphPad).
• Strong analytical and critical thinking skills with the ability to work in a fast-paced environment.
• Excellent written, oral, and presentation communication skills.
• Demonstrated ability to manage multiple priorities and deliver high-quality results in a fast-paced environment.

Skills

• Multicolor flow cytometry panel development
• Cell-based functional assays
• Murine model development
• Data analysis (Prism, Excel, MS Office)
• CRO management
• Scientific documentation and reporting
• Collaboration in cross-functional teams

Pay

$140,000 - $152,000 a year. Individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity, and work location.

Benefits

• Stock options, restricted stock units, and a stock purchase plan (ESPP)
• Annual targeted bonus
• 401k plan with flat non-elective employer contribution
• Comprehensive medical insurance with 90-100% employer-paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule, including summer and winter company shutdown
• Relocation assistance

Schedule

• Full-time, Monday to Friday
• On-site (San Diego, CA)