Sr Scientist, Drug Metabolism

About the Role

This position is onsite at our global headquarters in Foster City, CA.

Essential Duties and Job Responsibilities

• Provide advanced PK and PK/PD modeling expertise on project teams across discovery and development stages, guiding the design and interpretation of nonclinical PK, toxicology, and pharmacology studies.
• Drive quantitative DMPK strategy for programs, collaborating with interdisciplinary teams to integrate modeling approaches into decision-making; communicate modeling insights and align strategies with scientists, collaborators, and management.
• Design, implement, and validate complex PK/PD and mechanistic models to address translational questions, support dose selection, and predict first-in-human exposures.
• Develop and refine modeling workflows for nonclinical study design, including simulation-based approaches to optimize study parameters and interpret outcomes, with application of AI-based enhancements where possible.
• Work closely with project teams, line management and CROs to assure high quality and timely delivery of documents for regulatory submissions.
• Participate in business development and licensing evaluations.

Knowledge, Experience, and Skills

• Ph.D. with 5+ years of post-graduate industry experience in PK, drug metabolism, pharmaceutics, or a related life science field, with a primary focus on quantitative modeling of agents (small molecules, biologics, antibody-drug conjugates, targeted protein degraders etc.) for PK and PK/PD characterization across discovery and development.
• Strong foundation in PK and PD principles, with demonstrated ability to translate these concepts into mathematical models.
• Extensive experience in mechanistic PK/PD and multi-compartmental modeling, including proficiency with software platforms such as Phoenix/WinNonlin, MATLAB/SimBiology, GastroPlus, SimBiology, R, or equivalent modeling tools.
• Proven ability to design, implement, and interpret complex modeling workflows, determine next steps based on quantitative insights, and effectively communicate results to project teams and senior management.
• Hands-on experience in application of AI, in model-building and in streamlining and automation of workflows.
• Demonstrated intellectual curiosity and commitment to staying current with advances in biologics DMPK and modeling methodologies, supported by a track record of external visibility through publications, presentations, and/or professional organization involvement.
• Excellent communication skills, particularly the ability to explain complex topics to diverse audiences.

Pay

The salary range for this position is: $169,320.00 - $219,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.

Benefits

Benefits include company-sponsored medical, dental, vision, and life insurance plans*. For additional benefits information, visit https://www.gilead.com/careers/compensation-benefits-and-wellbeing. Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.