Senior Scientist, Translational PK/PD

Our department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization.

About the role

The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses, with supervision, guiding drug discovery strategy with a focus on biologics, protein therapeutics, and peptides.

Responsibilities

• Serve as PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas.
• Integrate in vitro and in vivo data to build PKPD, PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology, supporting forward/reverse translation for both established and novel therapeutic targets.
• Collaborate across PDMB and the broader Discovery/Translational organization to design experimental studies and modeling plans to identify and optimize drug candidates.
• Collaborate in the design of automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
• With guidance from experienced modelers, continue to build expertise and leadership skills in translational modeling and drug discovery.
• Demonstrate strong leadership and communication skills, drawing upon training and experience to enable model-informed drug discovery.

This role is available in South San Francisco, CA, West Point, PA, or Boston, MA based on candidate preference.

Qualifications

Education: Master's (with 3+ years), PharmD (with 1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics, or a related discipline. Experience with increasing responsibility and independence in drug discovery/development within industry, academia, regulatory, or non-profit settings.

Skills

• Required:
  • Experience performing hands-on translational PKPD modeling using standard modeling software (e.g., Matlab, OSP Suite, Monolix, R).
  • Strong skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and/or statistics.
  • Biostatistics, Data Analysis, Data Modeling, Data Science, Drug Discovery Process, Interdisciplinary Collaboration, MATLAB, Pharmacodynamics, Pharmacokinetics, PKPD Modeling, Statistical Analysis, Translational Pharmacokinetics and Pharmacodynamics (PKPD).
• Preferred:
  • Experience using mathematical modeling to inform decisions related to discovery/development of biologics, protein therapeutics, and/or peptides.
  • Demonstrated ability to work in interdisciplinary teams and in collaborative problem solving.
  • Expertise in developing novel PKPD, PBPK, QSP, or related mechanistic modeling approaches.

Pay

The salary range for this role is $129,000.00 - $203,100.00. An employee’s position within the salary range will be based on factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits, including:

• Medical, dental, vision healthcare, and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

Schedule

• Employee Status: Regular
• Relocation: Domestic/International available
• VISA Sponsorship: Yes
• Travel Requirements: 10%
• Flexible Work Arrangements: Hybrid
• Shift: 1st - Day