Postdoctoral Scholar, Translational PK/PD

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

About the role

The Translational PK/PD & Investigative Toxicology (TPPIT) team has strong expertise in characterizing ADCs and payloads from both experimental and modeling aspects. The scholar will work as part of a dynamic, cross-site team within a highly collaborative TPPIT environment, partnering with cross-functional colleagues across ADC data generation, analysis, and translational PK/PD modeling. This is a two-year position with the possibility of a third-year extension.

Responsibilities

• Advance translational PK/PD strategies for antibody-drug conjugates (ADCs) by integrating in vitro, preclinical, and clinical datasets to define exposure-response relationships.
• Build predictive in vitro models using 2D/3D cell culture systems and cell-based assays to characterize ADC and payload activity.
• Use experimental data, PK/PD modeling, and quantitative analysis to inform ADC candidate selection, support human dose projection, and reduce reliance on animal studies.

Requirements

• PhD with 0-1 years of experience.
• Preferred degrees in chemical or biomedical engineering or biopharmaceuticals.

Skills

• Required:
  • Wet-lab experience in cell culture, including 2D and 3D culture systems, and cell-based assays such as cytotoxicity assays; familiarity with microscopy and imaging techniques.
  • Proficiency in data analysis software such as Prism and ImageJ, and MATLAB or familiarity with at least one PK/PD modeling platform such as Monolix or Phoenix.
• Preferred:
  • Experience with cell and molecular biology assays, including the Incucyte live-cell analysis system; familiarity with PK/PD modeling.
  • ADC or drug conjugate experience.