Postdoctoral Scholar, Translational PK (Pharmacokinetics)/PD (Pharmacodynamics) and Investigative Toxicology (TPPIT)

About the role

The Department of Translational PK (Pharmacokinetics)/PD (Pharmacodynamics) and Investigative Toxicology (TPPIT) within Johnson & Johnson is seeking a Postdoctoral Scientist with expertise in the ADME characterization of proximity inducing degraders (e.g. PROTACs, molecular glues, RipTacs).

Responsibilities

• Develop translatable in vitro permeability models to mechanistically understand and improve the correlation between intrinsic permeability and fraction absorbed of PROTACs and other proximity inducing modalities.
• Evaluate the relative contribution of formulation-mediated lymphatic absorption and intestinal secretion to oral bioavailability using mechanistic in vivo studies and PBPK modeling.
• Integrate experimental data with computational modeling to identify molecular features that govern tissue permeability and enable rational design strategies for proximity-induced molecules.
• Provide interpretation of data and communicate/report results and recommendations to team members, key partners, and collaborators.
• Define and shape the TPPIT strategy for ADME characterization of proximity-inducing modalities.
• Trainings, development activities and conferences.
• Disseminate the results at internal and external meetings, and through publications in high impact journals.

Qualifications/Requirements

• A PhD in Pharmaceutical Sciences, Biology, Biochemistry, Pharmacology, Biomedical Sciences or a related field is required.
• Independent thinking and the ability to effectively collaborate in a highly matrixed environment is required.
• Track record of scientific contributions including peer reviewed publications, patents and/or presentations is required.
• Excellent oral and written communication skills are required.
• Ability to independently determine study design, execution, data analysis and interpretation of in vitro studies is required.
• Strong interest in practical in vitro studies and a keen interest in troubleshooting will be vital to ensure successful completion of the project.
• A strong interest in developing deep knowledge of the scientific literature is essential for success.
• Theoretical knowledge and practical experience with PROTACs is highly desired.
• Understanding of DMPK relevant areas such as pharmaceutics, pharmacokinetics, biotransformation, and PK/PD is preferred.
• Experience with analytical techniques (LC-MS/MS, HPLC/UPLC) is preferred.
• Experience in physiologically based pharmacokinetic (PBPK) modeling is preferred.
• Hands-on experience in culturing cell lines, primary cells, and organotypic models is preferred.

Pay

The anticipated base pay range for this position is $79,000.00 - $127,650.00. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan.