Senior Scientist, Translational Development

About the Role

Reporting to Director/Translational Development, this role is part of the translational group based in Cambridge, MA and will manage the scientific and preclinical laboratory component of multiple immune-oncology interfacing late-stage programs (phase 2 and beyond).

Key Responsibilities

• Performs preclinical/laboratory studies involving late-stage BMS assets to support annual goals and objectives for the Translational Medicine research group
• Responsible for delivering data in support of translational strategies including biomarkers, patient selection hypotheses, dose and schedule, combination strategies, resistance mechanisms and differentiation
• Interfaces with other research scientists within and outside of Translational Medicine to ensure seamless flow of information
• May contribute to external preclinical collaborations across the clinical asset pipeline
• Accurately maintain written reports and present results in an organized and timely manner
• Communicate effectively, foster teamwork and contribute to project strategy discussions

Qualifications & Experience

• PhD with at least 2 years of relevant work experience in an academic or industry setting focusing on immune-oncology, hematology and/or immunology
• Excellent publication record in high tier scientific journals and strong research track record in academic or industry setting, leading innovative efforts within the laboratory to achieve defined goals and support clinical development

Technical Skills

• In vitro: Multi-parameter flow cytometry and cell sorting in the context of primary immune cell characterization, cellular based immune effector assays (ADCC, ADCP, T-cell killing), cytokine analysis (ELISA/MSD), bulk/sc-RNA-seq
• In vivo: end-to-end syngeneic and CDX-based efficacy studies (i.v./p.o.), tumor immunophenotyping and transcriptomic profiling
• Experience with spatial technology platforms (e.g. Akoya, Visium, COSMX or similar) a plus
• Ability to work with disease teams/experts to develop preclinical strategies to support clinical development and life cycle management
• Strong verbal and written communication skills with experience in developing written documents such as primary manuscripts/publications are essential
• Strong commitment to quality, integrity, accountability and demonstrated adaptability
• Excellent communication, managerial and scientific qualities are expected
• High competency in scientific analysis, innovative solutions and the ability to strategically prioritize goals

Pay

Cambridge Crossing: $142,220 - $172,340. The starting pay range listed is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws.

Benefits

• Comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability)
• U.S.-based exempt employees: Flexible Time Off (FTO) with no set accrual limit (subject to manager approval), along with 11 paid company holidays each year
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico: 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays
• Additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
• Annual Global Shutdown between Christmas Day and New Year's Day