Senior Scientist / Principal Scientist / Director, Translational Research
for section headings. Use - for any list of duties/requirements/benefits, and
for prose.
We need to decide which sections to include: About the role (prose), Responsibilities (list), Requirements (list) maybe combine Qualifications and Preferred Experience? Could have Requirements (including qualifications) and maybe Skills (key competencies). Benefits (list). Ensure we don't create empty sections.
Let's extract content.
About the role: The first paragraph: "We are seeking a highly motivated and scientifically rigorous individual as a Senior Scientist, Principal Scientist, or Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be primarily responsible for identifying and validating development opportunities in multiple disease areas, and planning and performing proof-of-concept studies across preclinical in vitro and in vivo models. A second area of focus will be the development and implementation of potential predictive and pharmacodynamic biomarkers for Neomorph’s clinical studies.The role is highly cross-functional and will work closely with Research Biology, Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has deep biology expertise in human disease biology, strong translational research experience, and the ability to operate effectively in a fast-paced, small-company environment."
That's prose.
Responsibilities: bullet list under "Key Responsibilities" and then also biomarker responsibilities. Let's gather:
- Identify and validate development opportunities across the Neomorph pipeline in oncology and non-oncology.
- Design and oversee preclinical translational studies using in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling platforms.
- Support indication expansion, combination strategies, dose selection, and dose schedule optimization through translational research.
- Stay current with the target’s biology, competitors, and emerging therapeutic mechanisms.
- Oversee external vendors, academic collaborators, and CROs.
- Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data.
- Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions.
- Present translational data and strategy to internal leadership and external partners.
- Biomarker discovery, development, and clinical implementation:
- Develop and implement predictive biomarkers to support patient selection for Neomorph’s clinical studies.
- Develop and implement pharmacodynamic biomarkers for Neomorph’s clinical studies.
- Clinical biomarker strategies include tissue and blood-based assays, e.g., LC-MS, IHC/IF, NGS, ELISA, and other potential biomarker readouts.
- Oversee external vendors and CROs for clinical biomarker test development, validation, and analyses.
- Partner with Clinical Development/Operations to integrate biomarkers into Phase 1/2 clinical protocols and to implement biospecimen collection, processing, shipment, testing, and data analysis.
We can flatten bullet list.
Qualifications/Requirements:
- PhD, MD, MD/PhD, PharmD, or equivalent advanced degree in biology or genomics, molecular biology, translational medicine, or a related discipline.
- Sr. Scientist: 5+ years of relevant experience; Principal Scientist: 8+ years of relevant experience; or Director: 12+ years of relevant experience in drug discovery, translational research, and clinical biomarker development, with biotech/pharma experience preferred.
- Experience supporting programs in IND-enabling, Phase 1, and/or Phase 2 clinical development.
- Experience with in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling.
- Hands-on experience with biomarker assays such as e.g., LC-MS, IHC, IF, ctDNA, NGS, RNA-seq, flow cytometry, proteomics, single-cell methods, etc.
- Demonstrated ability to translate preclinical biology into clinical biomarker and patient-selection strategies.
- Experience managing CROs, academic collaborations, and external translational vendors.
- Strong data interpretation skills and ability to integrate complex biological, pharmacodynamic, and clinical datasets.
- Excellent written and verbal communication skills.
- Ability to work independently, prioritize effectively, and thrive in a fast-moving biotech environment.
Preferred Experience (maybe separate but could be part of Requirements or Skills). We'll include as part of Requirements or maybe a separate "Preferred Experience" section but we need headings only for defined list: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We could put preferred experience under Requirements or Skills. Probably better to include under Requirements (since it's experience). Or we could have a separate "Skills" section for key competencies.
Key Competencies:
- Scientific leadership and strategic thinking.
- Translational and clinical-development mindset.
- Strong human biology expertise.
- Cross-functional collaboration.
- Vendor and project management.
- Clear communication with scientific and non-scientific stakeholders.
- Hands-on problem-solving in a small-company environment.
- Ability to balance scientific rigor with practical execution.
We can put those under Skills.
Benefits: list from "What we offer:" and subsequent details.
Let's extract benefits:
- Industry-competitive compensation (maybe not specific, but it's a benefit statement; but we might include as part of Benefits? It's vague but it's a statement. The rule says avoid filler like "commensurate with experience". "Industry-competitive compensation" is somewhat vague but maybe acceptable as it's a benefit statement. However we might omit if we want to avoid filler. But we can include as a bullet point; it's not a specific number but it's a statement. The rule says never create Pay/Schedule/Benefits sections unless the posting actually states them. It does state "Industry-competitive compensation". That's a statement about compensation, albeit not specific. I'd include it as a benefit bullet.
- Annual target bonus
- Stock options
- 401K plan
- Career advancement opportunities
- Monthly town halls to share business and scientific updates
- Work Hard, Stay Well
- Comprehensive medical, dental, and vision plans for employees and their dependents
- Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
- Employee Assistance Program
- 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
- Supplemental pay for Pregnancy Disability Leave
- Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
- Lifestyle
- Casual work environment
- Volunteer days off each year to spend time contributing to causes you care about
- Flexible work schedule
- Access to onsite gym
- Onsite space to store your bicycle (or surfboard)
- Have Fun!
- We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
We can flatten into bullet list.
Now produce HTML.
Structure:
About the role
... prose ...
Responsibilities
- ...
...
Requirements
- ...
...
Skills
- ...
...
Benefits
- ...
...
We must not include Pay or Schedule sections.
Check that we didn't repeat job title as heading. Good.
Check we didn't include any boilerplate like EEO etc. We removed.
Now ensure we preserve all substantive information. Did we miss any? Let's verify.
From responsibilities we captured all bullet points. Did we miss "Stay current with the target’s biology, competitors, and emerging therapeutic mechanisms." Yes included.
"Oversee external vendors, academic collaborators, and CROs." included.
"Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data." included.
"Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions." included.
"Present translational data and strategy to internal leadership and external partners." included.
Biomarker responsibilities: we captured.
Now qualifications: we captured all bullet points.
Preferred experience: we haven't included. Should we include? The posting includes "Preferred Experience" bullet list. We need to preserve all substantive information. So we need to include Preferred Experience somewhere. Could be under Requirements or Skills. Since we have Requirements and Skills sections, we could add a subsection under Requirements for Preferred Experience, but we must not create new headings not in allowed list. We could incorporate preferred experience bullets into Requirements (makes sense as they are experience preferences). Or we could add them under Skills. I'll add them under Requirements as additional bullet points.
Preferred Experience bullets:
- Experience in oncology and at least one non-oncology disease area is a plus.
- Experience with PD biomarker development and predictive biomarker strategies for patient enrichment.
- Experience with targeted protein degradation is a plus.
- Prior experience contributing to IND submissions or early clinical oncology protocols.
- Familiarity with companion diagnostic or exploratory diagnostic development.
Add those.
Now Key Competencies we put under Skills.
Check we didn't miss any: "Ability to work independently, prioritize effectively, and thrive in a, fast-moving biotech environment." (note typo "a,") but we keep.
Now Benefits: ensure we captured all.
Let's list benefits bullets:
- Industry-competitive compensation
- Annual target bonus
- Stock options
- 401K
for prose. We need to decide which sections to include: About the role (prose), Responsibilities (list), Requirements (list) maybe combine Qualifications and Preferred Experience? Could have Requirements (including qualifications) and maybe Skills (key competencies). Benefits (list). Ensure we don't create empty sections. Let's extract content. About the role: The first paragraph: "We are seeking a highly motivated and scientifically rigorous individual as a Senior Scientist, Principal Scientist, or Director of Translational Research to lead translational strategy and execution for our pipeline. This individual will be primarily responsible for identifying and validating development opportunities in multiple disease areas, and planning and performing proof-of-concept studies across preclinical in vitro and in vivo models. A second area of focus will be the development and implementation of potential predictive and pharmacodynamic biomarkers for Neomorph’s clinical studies.The role is highly cross-functional and will work closely with Research Biology, Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has deep biology expertise in human disease biology, strong translational research experience, and the ability to operate effectively in a fast-paced, small-company environment." That's prose. Responsibilities: bullet list under "Key Responsibilities" and then also biomarker responsibilities. Let's gather: - Identify and validate development opportunities across the Neomorph pipeline in oncology and non-oncology. - Design and oversee preclinical translational studies using in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling platforms. - Support indication expansion, combination strategies, dose selection, and dose schedule optimization through translational research. - Stay current with the target’s biology, competitors, and emerging therapeutic mechanisms. - Oversee external vendors, academic collaborators, and CROs. - Collaborate with Bioinformatics/Biometrics to analyze and interpret translational datasets, including genomics, transcriptomics, proteomics, pharmacodynamic, and clinical outcome data. - Contribute to regulatory documents, including INDs, clinical protocols, investigator brochures, annual reports, and responses to health authority questions. - Present translational data and strategy to internal leadership and external partners. - Biomarker discovery, development, and clinical implementation: - Develop and implement predictive biomarkers to support patient selection for Neomorph’s clinical studies. - Develop and implement pharmacodynamic biomarkers for Neomorph’s clinical studies. - Clinical biomarker strategies include tissue and blood-based assays, e.g., LC-MS, IHC/IF, NGS, ELISA, and other potential biomarker readouts. - Oversee external vendors and CROs for clinical biomarker test development, validation, and analyses. - Partner with Clinical Development/Operations to integrate biomarkers into Phase 1/2 clinical protocols and to implement biospecimen collection, processing, shipment, testing, and data analysis. We can flatten bullet list. Qualifications/Requirements: - PhD, MD, MD/PhD, PharmD, or equivalent advanced degree in biology or genomics, molecular biology, translational medicine, or a related discipline. - Sr. Scientist: 5+ years of relevant experience; Principal Scientist: 8+ years of relevant experience; or Director: 12+ years of relevant experience in drug discovery, translational research, and clinical biomarker development, with biotech/pharma experience preferred. - Experience supporting programs in IND-enabling, Phase 1, and/or Phase 2 clinical development. - Experience with in vitro and in vivo models (e.g., cell lines, organoids, xenografts, PDX models, ex vivo patient samples) and relevant molecular profiling. - Hands-on experience with biomarker assays such as e.g., LC-MS, IHC, IF, ctDNA, NGS, RNA-seq, flow cytometry, proteomics, single-cell methods, etc. - Demonstrated ability to translate preclinical biology into clinical biomarker and patient-selection strategies. - Experience managing CROs, academic collaborations, and external translational vendors. - Strong data interpretation skills and ability to integrate complex biological, pharmacodynamic, and clinical datasets. - Excellent written and verbal communication skills. - Ability to work independently, prioritize effectively, and thrive in a fast-moving biotech environment. Preferred Experience (maybe separate but could be part of Requirements or Skills). We'll include as part of Requirements or maybe a separate "Preferred Experience" section but we need headings only for defined list: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We could put preferred experience under Requirements or Skills. Probably better to include under Requirements (since it's experience). Or we could have a separate "Skills" section for key competencies. Key Competencies: - Scientific leadership and strategic thinking. - Translational and clinical-development mindset. - Strong human biology expertise. - Cross-functional collaboration. - Vendor and project management. - Clear communication with scientific and non-scientific stakeholders. - Hands-on problem-solving in a small-company environment. - Ability to balance scientific rigor with practical execution. We can put those under Skills. Benefits: list from "What we offer:" and subsequent details. Let's extract benefits: - Industry-competitive compensation (maybe not specific, but it's a benefit statement; but we might include as part of Benefits? It's vague but it's a statement. The rule says avoid filler like "commensurate with experience". "Industry-competitive compensation" is somewhat vague but maybe acceptable as it's a benefit statement. However we might omit if we want to avoid filler. But we can include as a bullet point; it's not a specific number but it's a statement. The rule says never create Pay/Schedule/Benefits sections unless the posting actually states them. It does state "Industry-competitive compensation". That's a statement about compensation, albeit not specific. I'd include it as a benefit bullet. - Annual target bonus - Stock options - 401K plan - Career advancement opportunities - Monthly town halls to share business and scientific updates - Work Hard, Stay Well - Comprehensive medical, dental, and vision plans for employees and their dependents - Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution - Employee Assistance Program - 10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave. - Supplemental pay for Pregnancy Disability Leave - Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care - Lifestyle - Casual work environment - Volunteer days off each year to spend time contributing to causes you care about - Flexible work schedule - Access to onsite gym - Onsite space to store your bicycle (or surfboard) - Have Fun! - We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day). We can flatten into bullet list. Now produce HTML. Structure:
About the role
... prose ...
Responsibilities
- ... ...
Requirements
- ... ...
Skills
- ... ...
Benefits
- ... ...