Principal Scientist, Translational PK/PD Modeling

About the role

Build Our Future Together At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Prinicpal Scientist of Translational PK/PD Modeling to develop and implement quantitative and mechanistic PK/PD models to aid in the understanding of target biology, therapeutic modality selection/optimization, and contributes to early clinical trial dose selection and/or design and advancement and strategic direction of modeling and simulation sciences.

Responsibilities

• Independently develops and implements quantitative and mechanistic mathematical PK/PD models that inform preclinical-to-early clinical translation, including human efficacious dose predictions and first-in-human dose selection.
• Actively contributes to the advancement and strategic direction of modeling and simulation sciences
• Provides expert support to pre-clinical PK/PD project representatives and R&D project teams to design, execute and interpret in vitro and in vivo quantitative pharmacology studies. This included working with the Research PK group to optimize use of mouse PK data to inform translation to nonhuman primate and human PK.
• Effectively integrates and summarizes modeling and simulation analyses into useable information for multidisciplinary project teams.
• Remains apprised of emerging science and literature, and effectively collaborates with subject matter experts in Clinical Pharmacology, Quantitative Pharmacology and R&D to advance modeling and simulation sciences.
• Shares learnings and develops best practices across disease areas and therapeutic approaches.
• Committed to sharing technical expertise and the development / mentoring of others.