Sr. Scientist - Translational PBPK Modeling

The Drug Metabolism and Pharmacokinetics (DMPK) group is dedicated to enabling the discovery, development and commercialization of safe and effective medicines by elucidating the absorption, distribution, metabolism, excretion and pharmacokinetic properties of small molecule drug candidates. We accomplish this through the application of state-of-the-art technologies and sciences of bioanalysis, drug metabolism, drug transport and pharmacokinetics. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

Responsibilities

• Strategize, plan, execute, and report Physiologically-based Pharmacokinetic (PBPK) modeling and simulations independently.
• Present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences.
• Represent DMPK at multi-functional discovery and development project teams.
• Lead the DMPK strategy, including designing, executing, and reporting non-clinical studies.

Requirements

• PhD in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related scientific field.
• 2 years of relevant industry or post-doctoral experience in drug discovery/development.
• Expertise in PBPK modeling and quantitative pharmacology, with hands-on experience using platforms such as Simcyp, GastroPlus, or PK-Sim.
• Strong communication and organizational skills, with a track record of thriving within cross-functional team environments.

Preferred Qualifications

• Experience with additional modeling and simulation tools, such as Phoenix, R, NONMEM, SimBiology, or Python.
• Prior pharmaceutical industry experience as a DMPK project leader.
• Experience supporting diverse modalities (small/large molecules, peptides, etc.) in drug development or modeling.

This position offers domestic relocation.

Pay

The expected salary range for this position based on the primary location of San Francisco, CA is $124,300 - $230,900 USD. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

Benefits

This position qualifies for the benefits detailed at Genentech's benefits page.