Scientist – Ultrasound-Mediated Gene Delivery

About the role

Develop preclinical gene delivery approaches using focused ultrasound paired with viral and non-viral delivery technologies.

Systematically optimize focused ultrasound parameters against each delivery vehicle to maximize expression, spatial precision, and safety.

Collaborate with teams building the assays and readouts needed to quantify delivery, expression, and tolerability in brain tissue.

Design, run, and interpret in vivo experiments, iterating rapidly from data to the next round of optimization.

Evaluate emerging delivery technologies and help shape the team's longer-term delivery strategy.

Responsibilities

• Develop preclinical gene delivery approaches using focused ultrasound paired with viral and non-viral delivery technologies.
• Systematically optimize focused ultrasound parameters against each delivery vehicle to maximize expression, spatial precision, and safety.
• Collaborate with teams building the assays and readouts needed to quantify delivery, expression, and tolerability in brain tissue.
• Design, run, and interpret in vivo experiments, iterating rapidly from data to the next round of optimization.
• Evaluate emerging delivery technologies and help shape the team's longer-term delivery strategy.

Requirements

• A Ph.D. or equivalent experience leading research projects end-to-end in bioengineering, neuroscience, cell biology, molecular biology or a related field.
• Prior hands-on experience using focused ultrasound (FUS) to deliver genes to the brain in preclinical models.
• Demonstrated expertise in developing or optimizing gene delivery modalities.
• Developed and used methods to evaluate gene delivery and expression in brain tissues.
• Optimized focused ultrasound parameters to achieve specific expression goals.
• Worked on a delivery-related problem that is unusual or complex and loved it.
• Fun working on multidisciplinary teams, collaborating and communicating with experts across disciplines.

Qualifications

• The desire to be part of a fast-paced team working on frontier scientific and technical problems.

Skills

• Expertise in non-viral delivery modalities.
• Experience sourcing, evaluating, or in-licensing delivery technologies through external collaboration.
• Experience working with large animal models.

Benefits

N/A

Pay

$120K - $215K

Schedule

N/A