Senior Associate Scientist, Gene Engineering and Delivery

About the role

The Gene Engineering and Delivery team in the Cell Therapy Thematic Research Center is seeking a highly motivated scientist to advance next-generation cancer immunotherapies through molecular design, viral vector engineering, and gene delivery innovation. This role will focus on designing, cloning, characterizing, and producing viral vector constructs that enable development of CAR T cell therapies.

Responsibilities

• Execute molecular design and cloning of complex DNA constructs for cell therapy applications.
• Demonstrate competency in mammalian cell culture, transfection, and transduction of primary T cells.
• Develop molecular engineering designs and assays that support gene delivery and viral vector characterization.
• Produce viral vectors to enable gene delivery workflows and experimental evaluation.
• Design and clone DNA constructs to support CAR T cell therapy development.
• Culture mammalian cell lines for viral vector production, assessment, and gene delivery applications.
• Set up and run molecular characterization and cellular assays to evaluate viral vector performance.
• Develop, optimize, and document viral vector production and characterization protocols.
• Designs and executes experiments based on protocols.
• Collaborate with team members to assess the technical feasibility of novel gene delivery methods.
• Analyzes and interprets experimental data.
• Works within established procedures and in loosely defined problem-solving situations.
• Works under minimal supervision for both routine activities and non-routine activities.
• Makes decisions that impact own work and other group/team members.
• Participates on program/project teams, as needed.
• Maintain accurate, detailed electronic laboratory notebook records and supporting documentation.
• Summarize and present data in group meetings and written reports.

Qualifications

• Bachelor’s Degree in a scientific discipline and 4+ years of academic and/or industry experience, or
• Master’s Degree in a scientific discipline and 2+ years of academic and/or industry experience.

Preferred Qualifications

• Exceptional molecular biology skills, including molecular assay development, molecular design and cloning of complex DNA constructs, PCR, RT-PCR, and mRNA and DNA preparation.
• Experience with tissue culture techniques, including transfection of mammalian cell lines and transduction of T cells.
• Excellent organization, time management, and problem-solving skills with strong attention to detail.
• Ability to independently design and troubleshoot experiments.
• Outstanding written, visual, and oral communication skills.

Benefits

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