Scientist, R&D Chemistry, Peptidomimetic Synthesis

About the role

We are seeking a lab-centric peptide chemist to join the R&D Chemistry group at Regeneron. The ideal candidate will play a key role in developing peptidomimetic antibody-conjugate drug discovery capabilities, driving the synthesis and discovery of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics.

Responsibilities

• Drive the synthesis and discovery of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas.
• Troubleshoot and optimize peptide potency and stability using standard peptide-based principles (e.g., Ala scans), non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, and other medicinal chemistry strategies that are guided by in vitro assays, plasma/serum stability, and met ID data.
• Participate in the R&D Chemistry Peptidomimetic efforts on internal/external project teams, demonstrating the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron peptidomimetic conjugates.
• Identify new strategies and technologies to improve on existing Regeneron platforms for pursuing novel synthesis of peptidomimetic drug modality conjugates.
• Participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and represent the vision of the R&D Chemistry Peptidomimetic group.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

Requirements

• Bachelor’s degree required, Master’s degree preferred in peptide/peptidomimetic and/or synthetic organic chemistry (or related).
• Extensive hands-on experience of the synthesis and reaction troubleshooting of peptidomimetics, extensive experience running modern synthesis/isolation/characterization equipment and instrumentation.
• Expertise in modern methods of peptidomimetic synthesis and analytical characterization, and a minimum of 5-10 years of industry experience.
• A track record of success in the field of either peptidomimetics or small molecules is required.

Qualifications

• Passionate and enthusiastic about the promise of peptidomimetic conjugated, antibody-targeted therapeutics and appreciate the challenges and opportunities of drug delivery and molecular targeting.
• Comfortable working in a cross-functional role and excel as part of a diverse team where egos are checked at the door.
• Willing to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline.
• Modality agnostic, let the data determine the best course forward.

Skills

• Firm understanding and grasp of chemical biology strategies and the importance of applying both chemical and biological solutions to solve problems in drug discovery.
• Small molecule synthesis and drug discovery/SAR experience.
• Knowledge in the latest and most advanced peptide synthesis techniques, platforms, and strategies.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

Pay

$93,900.00 - $153,300.00 annually

Schedule

Full-time