Sr. Associate Scientist, R&D Chemistry, Peptidomimetic Purification

About the role

We are currently seeking a lab-centric peptide purification chemist to join the R&D (Research & Development) Chemistry group. In this position, they will play a key role in Regeneron's peptidomimetic antibody-conjugate drug discovery capabilities to enable seamless combination with the company's existing expertise in biologics and novel genetic medicines. The candidate will drive the purification of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups. Successful candidates will have a peptide/peptidomimetic purification background and will require a firm understanding of the latest techniques, strategies and instrumentation for HT peptide purification and isolation. We expect they will act as an inspiring and motivating colleague, effective communicator, and strong project team collaborator to help develop novel antibody-conjugated peptidomimetic therapeutics.

Responsibilities

• Actively participate and collaborate in the day-to-day activities of the R&D Chemistry Peptidomimetic purification team.
• Perform mass-triggered HPLC purification of novel peptidomimetic drug modalities, using modern purification instrumentation/detection and techniques.
• Troubleshoot and optimize peptide purification methods and enable high throughput purification and isolation.
• Identify new strategies and technologies for peptidomimetic purification to improve on existing Regeneron techniques.
• Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic purification team.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

Qualifications & Skills

• Bachelor's degree required, Master's degree preferred in peptide, peptidomimetic, or small molecule purification.
• Minimum of 5 years of industry experience.
• Extensive hands-on experience of the HPLC purification/detection and method troubleshooting of peptidomimetics.
• Hands-on experience with Waters and/or Agilent purifications systems preferred.
• Hands-on experience with mass-triggered collection preferred.
• Experience with high throughput purification.
• Extensive experience running modern purification/isolation equipment and instrumentation.
• A track record of success in the field of either peptidomimetics or small molecules purification is required.
• Working collaboratively with both internal and external organizations (e.g., CROs) is essential.

Pay

Salary range: $80,300.00 - $131,100.00 annually.