Associate Director, R&D Chemistry, Peptidomimetics

About the role

We are seeking an Associate Director to lead the R&D Chemistry Peptidomimetic group. The ideal candidate will drive the discovery of peptidomimetic antibody conjugate drug therapeutics, provide innovation and leadership, and build a pipeline of development candidates.

Responsibilities

• Directly supervise and manage the day-to-day activities of the R&D Chemistry Peptidomimetic group, providing vision, inspiration, and both short-term and long-term goals.
• Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group.
• Medicinal chemistry inspired and SAR-driven generation of novel peptidomimetic drug modalities, using synthetically feasible and simplistically designed linkers to provide overall optimal in vitro and in vivo properties of antibody-conjugated therapeutics.
• Champion and lead the R&D Chemistry Peptidomimetic efforts on internal/external project teams, demonstrating the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidates.
• Identify new strategies and technologies to improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of peptidomimetic drug modalities.
• Participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and represent the vision of the R&D Chemistry Peptidomimetic group.
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.

Requirements

• Ph.D. in peptide and/or synthetic organic chemistry or a related field.
• Minimum of 10 years of professional industry experience.
• Extensive drug discovery experience with antibody-targeted peptidomimetic drug modalities.
• Experience with the synthesis and manufacturing of peptidomimetic payloads and linkers.
• Expertise in modern methods in medicinal chemistry structure-activity relationships.
• A deep understanding of biological MOAs (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation).
• A track record of success in the field of either peptidomimetics, small molecules or antibody targeted therapeutics (i.e., advancement of molecules into the clinic).

Qualifications

• Firm understanding and grasp of chemical biology strategies and the importance of applying both chemical and biological solutions to solve problems in drug discovery.
• Small molecule synthesis and drug discovery/SAR experience.
• Knowledge in the latest and most advanced bioconjugation techniques, platforms, and strategies.

Skills

• Strong leadership and management skills.
• Effective communication and collaboration abilities.
• Ability to troubleshoot and optimize peptide potency and stability.
• Experience in peptide-based principles and medicinal chemistry strategies.
• Experience with linker and payload design.

Benefits

Build Our Future Together

Pay

$176,100.00 - $287,300.00 annually

Schedule

On-site position located in our Hawthorne, NY facility. Occasional travel to our nearby Tarrytown facility may be required.