Associate Director, R&D Chemistry, Peptidomimetics

We need to output HTML fragment with sections: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule as appropriate. Must include only sections with real specific content. No filler. Must not repeat job title as heading. Must not include Job ID etc. Must preserve all substantive info. Remove boilerplate like EEO, legal, application instructions, etc. We need to parse the posting. Key content: - Intro: "Associate Director (Peptidomimetics), R&D Chemistry We are currently seeking an established leader and drug hunter for the R&D (Research & Development) Chemistry group. In this position, they will play a key role in expanding the Regeneron peptidomimetic antibody-conjugate drug discovery capabilities, while providing innovation and leadership to seamlessly combine with the companys existing expertise in biologics and novel genetic medicines. The candidate will drive the discovery of peptidomimetic antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups. Successful candidates will have a peptidomimetic/synthetic organic/medicinal chemistry background and will require peptidomimetic synthesis, discovery and SAR (structure-activity relationship) optimization expertise as well as linker-payload synthesis experience. A firm understanding and grasp of chemical biology strategies and the importance of applying both chemical and biological solutions to solve problems in drug discovery will be key. Small molecule synthesis and drug discovery/SAR experience as well as knowledge in the latest and most advanced bioconjugation techniques, platforms, and strategies is desired. We expect they will act as an inspiring and motivating leader, effective communicator and manager, and strong collaborator to lead and drive project teams to develop novel antibody-conjugated peptidomimetic therapeutics. The successful candidate will also address challenges related to synthesis, medicinal chemistry, bioconjugation and optimal in vitro and in vivo properties leading to development candidates." Then "Build Our Future Together" bullet list of responsibilities. Then "When & Where" location info. Then "Discover Your Role" (maybe about candidate traits) but could be part of Requirements/Qualifications. Then "In order to be considered qualified for the role, you must have:" list of qualifications. Then "Does this sound like you? Apply now..." (application instruction, remove). Then EEO etc (remove). Then benefits description: "Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits." Then link for US benefits. Then "For other locations, additional information will be provided during the recruitment process." Then "If you have any questions, please speak with your recruiter." Then "Please be advised that at Regeneron, we believe we do our best work when we are together..." (onsite expectation) maybe part of Schedule? Actually it's about onsite expectations. Then background check info. Then "For jobs in Canada: this posting is for an existing position. Salary Range (annually) $176,100.00 - $287,300.00" Thus we have salary range. We need sections: About the role (intro paragraph), Responsibilities (list from "Build Our Future Together"), Requirements (maybe the qualifications list), Qualifications (maybe overlapping? Could combine but we need separate sections only if content exists). Skills maybe from "Discover Your Role" traits. Benefits from benefits paragraph. Pay from salary range. Schedule from onsite expectation? The posting mentions "This is an on-site position located in our Hawthorne, NY facility Occasional travel to our nearby Tarrytown facility may be required". That's schedule/location info. Could be Schedule section. We must not create sections with filler like "commensurate with experience". We have actual content. Thus sections:

About the role

...intro paragraph...

Responsibilities

• ... each bullet from Build Our Future Together...

Requirements

• ... list from "In order to be considered qualified for the role, you must have:"

Maybe also

Skills

from "Discover Your Role" bullet points (passionate..., enjoy..., comfortable..., want..., prefer...). Those are traits/skills.

Benefits

...benefits paragraph...

Pay

Salary Range (annually) $176,100.00 - $287,300.00

Schedule

This is an on-site position located in our Hawthorne, NY facility. Occasional travel to our nearby Tarrytown facility may be required.

We must ensure we don't include duplicated lines. Also remove any navigation/legal/EEO etc. Check for any other substantive content: "Build Our Future Together Directly supervise and manage the day-to-day activities of the R&D Chemistry Peptidomimetic group, providing vision, inspiration, and both short-term and long-term goals. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group.Perform medicinal chemistry inspired and SAR-driven generation of novel peptidomimetic drug modalities, using synthetically feasible and simplistically designed linkers to provide overall optimal in vitro and in vivo properties of antibody-conjugated therapeuticsTroubleshoot and optimize peptide potency and stability using standard peptide-based principles (e.g., Ala scans), non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, and other medicinal chemistry strategies that are guided by in vitro assays, plasma/serum stability, and met ID data.Champion and lead the R&D Chemistry Peptidomimetic efforts on internal/external project teams, and demonstrate the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidatesIdentify new strategies and technologies (e.g., linker and payload design) to improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of peptidomimetic drug modalitiesActively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic group.Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations." We need to split into list items. Ensure each item ends with a period. We'll extract each sentence as a bullet. Sentences: 1. Directly supervise and manage the day-to-day activities of the R&D Chemistry Peptidomimetic group, providing vision, inspiration, and both short-term and long-term goals. 2. Communicate priorities, policies, and goals of Regeneron Senior Leaders to the group. 3. Perform medicinal chemistry inspired and SAR-driven generation of novel peptidomimetic drug modalities, using synthetically feasible and simplistically designed linkers to provide overall optimal in vitro and in vivo properties of antibody-conjugated therapeutics 4. Troubleshoot and optimize peptide potency and stability using standard peptide-based principles (e.g., Ala scans), non-natural amino acid incorporation, alpha-Me/N-Me peptide backbone modifications, and other medicinal chemistry strategies that are guided by in vitro assays, plasma/serum stability, and met ID data. 5. Champion and lead the R&D Chemistry Peptidomimetic efforts on internal/external project teams, and demonstrate the ability to multi-task and parallel process to add to our continuous pipeline of Regeneron development candidates 6. Identify new strategies and technologies (e.g., linker and payload design) to improve on existing Regeneron platforms for pursuing novel synthesis and bioconjugation of peptidomimetic drug modalities 7. Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic group. 8. Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations. Now Requirements list from "In order to be considered qualified for the role, you must have:": - Ph.D. in peptide and/or synthetic organic chemistry or a related field. - Minimum of 10 years of professional industry experience. - Extensive drug discovery experience with antibody-targeted peptidomimetic drug modalities, experience with the synthesis and manufacturing of peptidomimetic payloads and linkers, expertise in modern methods in medicinal chemistry structure-activity relationships, and a deep understanding of biological MOAs (extracellular/intracellular target evaluation, ADME/PK, PD/efficacy, toxicological evaluation). - A track record of success in the field of either peptidomimetics, small molecules or antibody targeted therapeutics (i.e., advancement of molecules into the clinic) with experience building and leading teams is required. We could split into separate bullets each line. Now Skills from "Discover Your Role": - You are passionate and enthusiastic about the promise of peptidomimetic conjugated, antibody-targeted therapeutics and appreciate the challenges and opportunities of drug delivery and molecular targeting. - You enjoy applying and combining traditional methods and novel technologies to develop solutions for synthesis, bioconjugation and drug discovery. - You are comfortable working in a cross-functional role and excel as part of a diverse team where egos are checked at the door. - You want to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline. - You prefer to work in an organization that is modality agnostic, letting the data determine the best course forward. We can phrase as bullet points. Now Benefits paragraph: "Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits." We could keep as paragraph. Now Pay: salary range. Now Schedule: onsite location and occasional travel. Now About the role paragraph: combine the introductory paragraph(s) before "Build Our Future Together". Let's extract that: "We are currently seeking an established leader and drug hunter for the R&D (Research & Development) Chemistry group. In this position, they will play a key role in expanding the Regeneron peptidomimetic antibody-conjugate drug discovery capabilities, while providing innovation and leadership to seamlessly combine with the companys existing expertise in biologics and novel genetic medicines. The candidate will drive the discovery of peptidomimetic antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups. Successful candidates will have a peptidomimetic/synthetic organic/medicinal chemistry background and will require peptidomimetic synthesis, discovery and SAR (structure-activity relationship) optimization expertise as well as linker-payload synthesis experience. A firm understanding and grasp of chemical biology strategies and the importance of applying both chemical and biological solutions to solve problems in drug discovery will be key. Small molecule synthesis and drug discovery/SAR experience as well as knowledge in the latest and most advanced bioconjugation techniques, platforms, and strategies is desired. We expect they will act as an inspiring and motivating leader, effective communicator and manager, and strong collaborator to lead and drive project teams to develop novel antibody-conjugated peptidomimetic therapeutics. The successful candidate will also address challenges related to synthesis, medicinal chemistry, bioconjugation and optimal in vitro and in vivo properties leading to development candidates." We can keep as a single paragraph. Now ensure no