Scientist, mRNA Downstream Purification

About NewLimit NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale. Position We are seeking a Scientist to lead downstream process development for the mRNA Engineering team. In this role, you will design, optimize, and scale purification processes for mRNA drug substance. This is a hands-on, lab-based role that spans program process development and platform engineering. It is ideal for a scientist who enjoys solving purification challenges and scaling processes in a dynamic, fast-paced environment. What you'll do As a Member Of Our Team, You Will Develop downstream purification processes Design, execute, and analyze process development studies for mRNA purificationAct as the downstream lead for CMC program teamsHelp design and implement automated downstream workflows for high-throughput purification of research-grade mRNASupport execution of research-grade mRNA production runs for discovery and preclinical studies, as neededSupport process scale-up from bench to pilot scale, as neededEvaluate emerging purification technologies and chromatography resins Support tech transfer and CDMO manufacturing Perform tech transfer of downstream processes to CDMOsAct as person in plant during CDMO manufacturing runsSupport process troubleshooting and deviation investigations at CDMOs Documentation and collaboration Maintain organized experimental records in Electronic Lab NotebooksAuthor development SOPs and technical development reportsPresent experiment results at team meetings Requirements Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experienceHands-on experience developing downstream purification processes for nucleic acids or other biologicsHands-on experience with tangential flow filtration (TFF)Experience operating ÄKTA chromatography systemsAbility to independently design, execute, and troubleshoot experimentsAbility to analyze and present complex data setsStrong technical writing skillsExcellent communication and organizational skills Nice to have Experience with traditional nucleic acid purification methods (e.g., desalting, precipitation, size-exclusion)Experience with plasmid DNA purificationExperience with Design of Experiments (DoE) and statistical data analysisExperience implementing automated or high-throughput purification workflowsExperience with process transfer to CDMOsGeneral understanding of cGMP and phase-appropriate process developmentFamiliarity with mRNA analytics such as HPLC, CGE, and dsRNA ELISA Benefits NewLimit offers generous benefits to ensure our team can focus on our mission: Health, dental, and vision insurance401(k) with company matchPaid parental leaveIndustry-leading paid time off (PTO) — 20 days/year for all employees + holidaysMeals and snacks on-site Salary Range: $120,000-155,000*. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.