Scientist, Purification, RNA Process Development
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). Do NOT repeat the job title as a heading. Do NOT put Job ID / requisition numbers as headings — fold minor metadata into a short
or drop it. Preserve ALL substantive information; do NOT invent or summarize away detail. Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. IMPORTANT: include a section ONLY when the posting has real, specific content for it — never emit a heading followed by filler/placeholder text (e.g. "commensurate with experience", "not specified", "N/A", "varies", "TBD") and never create Pay/Schedule/Benefits sections unless the posting actually states them. We have content: Position Summary (maybe About the role). Key Responsibilities (list). Qualifications & Experience (list). Compensation Overview (Pay). Benefits (Benefits). How We Work (maybe Schedule? Actually schedule not given; but we have work models: site-essential, site-by-design, field-based and remote-by-design. That could be Schedule? Not exactly schedule but work model. The instruction says use Schedule heading only if posting actually states them. It does mention work models but not schedule like hours. Might be better to not include Schedule unless explicit. We have Benefits section. Pay section present. Also we have "How We Work" maybe could be under "About the role" or separate? The instruction list includes About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We can map: About the role = Position Summary + company purpose paragraph. Responsibilities = Key Responsibilities (list). Requirements = maybe Qualifications & Experience (list). Could also separate Skills but we can combine. Benefits = Benefits section. Pay = Compensation Overview. Schedule: not present; we have work models but not explicit schedule; maybe we can omit Schedule. We must not include boilerplate like EEO, disability, data protection, etc. Also remove application instructions like "To check your application status..." etc. Also remove duplicated lines. We need to preserve all substantive information: company purpose paragraph, position summary, responsibilities list, qualifications list, compensation details, benefits details, work models maybe? The work models are under "How We Work". That is substantive; we could include under "About the role" or maybe a separate section like "Work Model". But not in allowed headings; we could incorporate into About the role as a paragraph. We must not invent or summarize away detail. So we need to keep the exact text? We can rephrase but must preserve meaning. Safer to keep the sentences as is, maybe slightly trimmed but not lose info. Let's extract: Company purpose paragraph: "At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it." Position Summary: "The RNA Purification Process Development function plays a central role in designing efficient, robust, and scalable manufacturing processes. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Scientist executes robust experiments for drug substance programs spanning early- to late-stage development across circular and linear mRNA modalities. Reporting to the Principal Scientist, this role encompasses hands-on contributions, addressing critical challenges by driving sound experimental execution and manufacturing support. The candidate should be driven by developing and characterizing chromatography and filtration steps for improving the yield, quality and robustness of purification process steps." Key Responsibilities list (bullet points): - Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling - Define the RNA drug substance purification process, the critical parameters, and the design space - Experiment using high throughput/automated or data rich experimental setups - Design experiments to confirm robust process performance across the control space - Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles - Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity - Prepare technical reports, and communicate findings internally and externally as appropriate - Participate in tech transfer activities to GMP manufacturing sites for RNA programs Qualifications & Experience list: - Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field - BS with 6+ years’ experience in science related disciplines - MS with 4-6 years’ experience in science related disciplines - PhD with 0 - 2 years’ experience in science related disciplines - Expertise in chromatography, filtration (TFF/UF-DF), and innovative separation unit operations - Solid knowledge foundation of statistical design of experiments (DoE) and analysis of multivariate data - Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis - Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing - Demonstrated background of providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications - Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus - Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus Compensation Overview: - Cambridge - MA - US: $110,810 - $134,281 - The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. - We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. - Final compensation is guided by pay equity principles and applicable employment laws. - Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance. Benefits: - Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). - U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. - Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays. - Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. - Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day. - U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits How We Work (work models): - Where you work matters – because collaboration, innovation and patient impact happen in many settings. - Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. - The model assigned to this role is based on its core responsibilities. - Learn more at https://careers.bms.com/ways-of-working. We should not include the "Supporting People With Disabilities", "Candidate Rights", "Data Protection", etc. Now produce HTML with headings
for each section we include: About the role, Responsibilities, Qualifications, Benefits, Pay. Possibly also "Work Model" but not in list; we could incorporate into About the role as a paragraph.
We must not include empty sections. Ensure we don't include filler like "commensurate with experience". Not present.
We need to output only HTML fragment, no /, no markdown.
Let's craft:
About the role
At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.
The RNA Purification Process Development function plays a central role in designing efficient, robust, and scalable manufacturing processes. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Scientist executes robust experiments for drug substance programs spanning early- to late-stage development across circular and linear mRNA modalities. Reporting to the Principal Scientist, this role encompasses hands-on contributions, addressing critical challenges by driving sound experimental execution and manufacturing support. The candidate should be driven by developing and characterizing chromatography and filtration steps for improving the yield, quality and robustness of purification process steps.
Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.
Responsibilities
- Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling
- Define the RNA drug substance purification process, the critical parameters, and the design space
- Experiment using high throughput/automated or data rich experimental setups
- Design experiments to confirm robust process performance across the control space
- Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles
- Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity
- Prepare technical reports, and communicate findings internally and externally as appropriate
- Participate in tech transfer activities to GMP manufacturing sites for RNA programs
Qualifications
- Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
- BS with 6+ years’ experience in science related disciplines
- MS with 4-6 years’ experience in science related disciplines
- PhD with 0 - 2 years’ experience in science related disciplines
- Expertise in chromatography, filtration (TFF/UF-DF), and innovative separation unit operations
- Solid knowledge foundation of statistical design of experiments (DoE) and analysis of multivariate data
- Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
- Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing
- Demonstrated background of providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications
- Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
- Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus
Pay
Cambridge -