Scientist I, Discovery DMPK

About the role

Arrowhead Pharmaceuticals is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics. As a member of the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team, you will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results. A successful candidate will demonstrate strong technical expertise in LC-MS, along with excellent problem-solving and communication abilities.

Responsibilities

• Perform LC-MS based quantitative bioanalysis in biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
• Support the identification of drug candidate metabolites.
• Process, review, and interpret data independently.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Understand experiment designs, generate figures to present data accordingly, and share bioanalysis results to cross-functional groups.
• Set up and maintain lab instruments.
• Maintain a well-documented laboratory notebook. Document experimental procedure and results accurately and meticulously.
• Demonstrate sample analysis, troubleshooting and problem-solving skills.
• Execute assays in a timely manner to meet deadlines.
• Be able to address questions or concerns related to bioanalysis running conditions and data analysis criteria.
• Adhere to safe laboratory practices.

Requirements

• Bachelor of Science in Biology or related field and a minimum of 8 years of experience in chemistry, biology, or a related field (or Master's degree and 5 years of experience)
• Experience with LC-MS
• Hands-on experience of sample handling from biological matrices.
• Demonstrated innovation, creativity and resilience in problem solving.
• Excellent oral and written communication skills.
• Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment.

Preferred

• Experience with high-resolution mass spectrometry, ideally applied to oligonucleotide therapeutics.
• LC-MS method development or validation experience.

Pay

Wisconsin pay range $88,000–$100,000 USD