Scientist I, Discovery DMPK

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins. Arrowhead’s RNAi technologies enable addressing conditions across virtually any therapeutic area, including disease targets not otherwise addressable by small molecules and biologics. The company leads the field in bringing RNAi therapies to diseases outside the liver, with a clinical pipeline targeting the liver and lung, and a promising preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

Arrowhead Pharmaceuticals is seeking a Scientist to support pharmacokinetic analysis of RNAi-based therapeutics. As a member of the Discovery Drug Metabolism and Pharmacokinetics (DMPK) team, you will analyze biological samples using high-resolution LC-MS, quantify drug candidates and their metabolites, and guide interpretation of results. A successful candidate will demonstrate strong technical expertise in LC-MS, along with excellent problem-solving and communication abilities.

Responsibilities

• Perform LC-MS based quantitative bioanalysis in biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
• Support the identification of drug candidate metabolites.
• Process, review, and interpret data independently.
• Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
• Understand experiment designs, generate figures to present data accordingly, and share bioanalysis results with cross-functional groups.
• Set up and maintain lab instruments.
• Maintain a well-documented laboratory notebook. Document experimental procedures and results accurately and meticulously.
• Demonstrate sample analysis, troubleshooting, and problem-solving skills.
• Execute assays in a timely manner to meet deadlines.
• Address questions or concerns related to bioanalysis running conditions and data analysis criteria.
• Adhere to safe laboratory practices.

Requirements

• Bachelor of Science in Biology or related field and a minimum of 8 years of experience in chemistry, biology, or a related field (or Master's degree and 5 years of experience).
• Experience with LC-MS.
• Hands-on experience of sample handling from biological matrices.
• Demonstrated innovation, creativity, and resilience in problem-solving.
• Excellent oral and written communication skills.
• Self-motivated team player with the ability to thrive in a fast-paced, dynamic, multi-disciplinary, matrixed environment.

Qualifications

• Experience with high-resolution mass spectrometry, ideally applied to oligonucleotide therapeutics.
• LC-MS method development or validation experience.

Pay

Wisconsin pay range: $88,000–$100,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.