Associate Scientist II, Discovery DMPK

About the Company

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference (RNAi) mechanism to induce rapid, deep, and durable knockdown of target genes. RNAi is a natural pathway in living cells that inhibits gene expression, affecting protein production. The company focuses on innovative drugs for genetically based diseases, often characterized by protein overproduction. Arrowhead’s RNAi technologies enable addressing conditions across virtually any therapeutic area, including targets not addressable by small molecules and biologics. The company leads in expanding RNAi applications beyond the liver, with a clinical pipeline targeting liver and lung diseases and a robust preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the Role

The Associate Scientist will join the Discovery DMPK group within the Chemistry Department, focusing on analyzing biological samples using state-of-the-art LC-MS (high-resolution mass spectrometry preferred) and qPCR assays to support discovery programs.

Responsibilities

• Perform LC-HRMS or stem-loop qPCR-based quantitative bioanalysis in various biological matrices (fluids and tissues) to support pharmacokinetics and tissue clearance studies.
• Understand and follow sample preparation protocols applicable to assigned tasks.
• Document experimental procedures and results accurately and meticulously.
• Execute all assays in a timely manner to meet deadlines.

Requirements

• Bachelor of Science in Chemistry, Biology, Biochemistry, or a related field.
• 3+ years of laboratory experience.
• Hands-on experience with LC-MS or multiple detection techniques.
• Hands-on experience handling biological matrices.
• Demonstrated innovation, creativity, and resilience in problem-solving.
• Excellent oral and written communication skills.
• Self-motivated team player able to thrive in a fast-paced, multi-disciplinary, matrixed environment.

Preferred Qualifications

• Practical understanding of liquid chromatography and mass spectrometry.
• Experience with high-throughput sample analysis using bioanalysis assays.
• Experience working with oligonucleotides.

Pay

Wisconsin pay range: $70,000–$80,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefits package.

Candidates must have current, valid authorization to work in the country where this role is located.