Scientist I, DMPK

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, currently in clinical development.

About the role

The DMPK Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

Responsibilities

• Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples (blood, plasma, tissue, urine, bile, etc.), and perform metabolite profiling and structural elucidation.
• Characterize major, unique, or disproportionate metabolites to support candidate selection, MIST (Metabolites in Safety Testing) analysis, and metabolite regulatory strategy.
• Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities.
• Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.
• Build and maintain strong collaborative partnerships across functional areas, e.g., Discovery research, Clinical Pharmacology, Medicinal Chemistry, Pharmaceutical Development, Toxicology, and Translational Research.

Requirements

• PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, with more than 2 years of experience after graduation.
• Demonstrated hands-on experience in metabolite profiling using high resolution mass spectrometry.
• Solid understanding of drug metabolism, pharmacokinetics, and ADME principles.
• Demonstrated hands-on experience in using PK software (e.g., WinNonlin).
• Excellent verbal and written communication, problem-solving, and critical thinking skills.
• Ability to independently design experiments, analyze data, and communicate results.

Preferred Qualifications

• Prior experience with oncology drug discovery.
• Previous experience with PBPK modeling and DDI risk assessment.
• Effective communication and documentation skills.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $119,000 - $149,000 USD. The range will be adjusted for the local market a candidate is based in. Individual base pay salary is determined by job-related skills, experience, market dynamics, and relevant education or training.

Benefits

Total rewards at Revolution Medicines include competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.