Scientist - Cell Biology

About the role

In this role, you will:

• Develop, maintain, or optimize mammalian cell preparations, including cell lines, primary and iPSC-derived neurons, brain organoids, or brain slices.
• Collaboratively design and build novel protein and genetic constructs to enable biosensing and/or actuation functionality.
• Develop and perform cell engineering workflows, including construct delivery, selection, and/or differentiation.
• Characterize construct functionality and cellular burden using activity recording, microscopy, stimulation, flow cytometry, immunohistochemistry, and/or next-gen sequencing.
• Collaborate with cross-disciplinary teams integrating protein engineering, biochemistry, cell biology, neuroscience, genetics, research platform, and computational methods.
• Recruit and mentor research associate(s) as needed to expand efforts.

Responsibilities

You will:

• Engineer neurons and other cell types to express novel molecular biosensors and/or actuators and evaluate their functionality in enabling cells to interact with ultrasound.
• Study their expression, localization, degradation and impact on cell function and health.
• Develop protocols for culture, analysis, microscopy, and coupling with physical energy such as ultrasound.

Requirements

You might thrive in this role if you have:

• A Ph.D. or equivalent experience leading research projects end-to-end in neuroscience, cell biology, molecular biology, bioengineering, or a related field.
• Demonstrated expertise in neuronal cell culture and engineering.
• Experience with primary neurons, human iPSC-derived neurons, brain organoids, and/or acute/organotypic brain slices highly preferred.
• Knowledge of cell pathologies, metabolism, proteostasis, protein trafficking and/or epigenetics.
• Experience with high-throughput screening, tissue clearing, advanced microscopy, next-gen sequencing, or spatial transcriptomic techniques highly preferred, but not required.
• Programming and data analysis skills (Python, MATLAB, or ImageJ/Fiji).
• A love of new methods and scientific challenges.
• A fun working on multidisciplinary teams, collaborating and communicating with experts across disciplines.

Qualifications

You must have:

• A Ph.D. or equivalent experience leading research projects end-to-end in neuroscience, cell biology, molecular biology, bioengineering, or a related field.
• Demonstrated expertise in neuronal cell culture and engineering.
• Experience with primary neurons, human iPSC-derived neurons, brain organoids, and/or acute/organotypic brain slices.
• Knowledge of cell pathologies, metabolism, proteostasis, protein trafficking and/or epigenetics.
• Experience with high-throughput screening, tissue clearing, advanced microscopy, next-gen sequencing, or spatial transcriptomic techniques.
• Programming and data analysis skills (Python, MATLAB, or ImageJ/Fiji).

Skills

You should have:

• A love of new methods and scientific challenges.
• A fun working on multidisciplinary teams, collaborating and communicating with experts across disciplines.

Benefits

Nice to have:

• Experience with protein or gene circuit engineering.
• Experience with electrophysiology and/or neural circuit interrogation.

Pay

$120K - $215K

Schedule

Not specified