Scientist - Cell Biology

Key Responsibilities

• Assay Design & Execution: Design, optimize, and perform robust cell-based functional assays (e.g., cytotoxicity, internalization, proliferation, and receptor binding) to evaluate antibody and ADC candidates.
• Cell Engineering & Culture: Utilize CRISPR or lentiviral systems to generate engineered knockout, knockdown, or overexpressing cell lines to model specific glycan targets. Maintain a diverse bank of cancer cell lines and use single-cell sorting to generate lead clones.
• Flow Cytometry & Imaging: Perform multi-parameter flow cytometry (surface staining, intracellular staining, profiling) to quantify therapeutic efficacy and cellular mechanisms.
• Data Analysis & Rigor: Analyze complex datasets, interpret biological mechanisms, maintain pristine laboratory records, and build decision-focused data packages.
• Cross-Functional Collaboration: Partner seamlessly with our proteomics and antibody discovery teams, presenting clear, concise scientific conclusions to project teams and external collaborators.

Qualifications & Experience

• Education: PhD in Cell Biology, Cancer Biology, Immunology, or a related discipline with 1–3 years of relevant post-PhD or industry experience, OR an MS with 7+ years of industry experience demonstrating increasing scientific independence.
• Technical Core Competencies:
  • Extensive experience with aseptic cell culture techniques, maintaining mammalian cancer cell lines, and primary cells.
  • Extensive experience directly working with antibodies and antibody-based drug candidates.
  • Proven expertise in multi-color flow cytometry (panel design, acquisition, and data analysis using FlowJo).
  • Hands-on experience with quantitative cell biology techniques (e.g., ELISA, Western Blot, MSD).
• Soft Skills & Attributes:
  • Analytical Mindset: Exceptional problem-solving skills focused on hypothesis generation and experimental validation.
  • Operational Excellence: Excellent organizational and time-management abilities to balance multiple priorities.
  • Strategic & Entrepreneurial Thinking: An entrepreneurial thinker who actively contributes to overall research goals and drug development strategy.
  • Collaboration & Communication: A team-first attitude with the ability to work independently, paired with strong written and verbal communication skills, and the ability to mentor junior Scientists and Research Associates.
• Preferred Qualifications: Prior experience working with post-translational modifications, glycoproteins, or glycosylation pathways and/or antibody-drug conjugate biology is a plus.

What We Offer

• Equity in a promising start-up.
• Comprehensive health coverage.
• 401k & paid time off.
• Opportunities for professional growth and development.
• Compensation based on experience.