Scientist 3 - CVRM Discovery / Research Biology

Key responsibilities

• Independent design, execution and interpretation of experiments; including brainstorming of next steps and troubleshooting
• Willingness to mentor/cross-train colleagues
• Ability to present research at intra- and inter-departmental meetings
• Communicate findings through high-quality internal presentations, cross-functional forums, and external publications/conferences
• Timely adherence to ELN

Qualifications

• Education: PhD in a life science discipline (e.g., cell biology, biochemistry) or a Bachelor’s/Master’s degree with equivalent industry experience
• Track Record: Demonstrated achievement through high-quality publications and a strong understanding of cardiovascular and metabolic disease biology
• Experimental Design: Skilled in independent, controlled experimental design and literature review to drive mechanism-of-action studies
• Cell Culture: Proficient in culturing mammalian cell lines and primary cells (cardiomyocytes, immune cells, organoids, etc.)
• Molecular Methods: Experienced in cell line manipulation (e.g., CRISPR, shRNA, lentivirus) and characterization (e.g., qRT-PCR, RNAseq, Western Blot, ELISA)
• Tissue Analysis: Capable of ex-vivo tissue isolation and downstream processing (e.g., protein/RNA isolation)
• Assay Proficiency: Competent in plate-reader based assays, reporter assays, dose-response curve generation, and statistical analysis
• Communication: Strong interpersonal skills with the ability to present research in cross-functional forums
• Preferred Background and Skills: Experience with imaging technologies (e.g., Incucyte, immunofluorescence), flow cytometry, and protein methods (e.g., IP). Industry experience, familiarity with cardiovascular models, and experience or willingness to develop in vivo models.