Scientist 3 - CVRM Discovery Biology

About the role

Create and validate disease-relevant cellular and animal models to test target biology and therapeutic hypotheses. Generate, analyze, and interpret data to define the role of novel targets in disease-relevant pathways and physiology. Deliver decision-enabling results for early drug discovery programs.

Responsibilities

• Design and execute in vitro and in vivo experiments to uncover molecular mechanisms underlying cardiovascular, renal, and metabolic disease.
• Contribute to the progression of cardiometabolic programs by delivering high-quality, reproducible data.
• Participate in experimental planning and provide scientific input to project strategy discussions.
• Maintain accurate documentation of experimental work and ensure data integrity.
• Work closely with the Lab Head and cross-functional teams across Research, Computation, Translational Medicine, and Drug Development.
• Present data at internal meetings and contribute to external publications and scientific conferences.
• Collaborate effectively with multidisciplinary teams to achieve project milestones.

Requirements

PhD in a life science discipline (e.g., Metabolism, Cell Biology, Genetics, or a related field) or a Master’s or Bachelor’s degree with post doc or equivalent industry experience. Strong foundation in metabolic disease, cardiovascular disease, and/or immunology. Proven track record through high impact publications in metabolic disease research. Demonstrated ability to design and execute experiments independently and analyze complex datasets. Track record of independent research to conceive ideas, develop studies and derive conclusions as demonstrated by high profile publications. Excellent organizational, communication, and collaboration skills, with enthusiasm for working in a cross-functional environment.

Preferred qualifications

• Proficiency in advanced in vitro models—such as human primary cells and organoids—paired with experience using CRISPR, RNAi, and other gene perturbation methods.
• Hands-on experience with metabolic, biochemical, receptor pharmacology, or cell-based assays to study lipid handling, mitochondrial function, insulin/GPCR signaling, intercellular communication, or energy homeostasis; familiarity with high-content imaging or flow cytometry is a plus.
• Practical experience with in vivo disease models—including obesity, diabetes, and cardiometabolic conditions—as well as associated tissue processing and extraction.
• Specialized knowledge in metabolism, energy homeostasis, appetite regulation, and cardiovascular, renal, or related disease areas.

Skills

Strong foundation in metabolic disease, cardiovascular disease, and/or immunology. Proven track record through high impact publications in metabolic disease research. Demonstrated ability to design and execute experiments independently and analyze complex datasets. Track record of independent research to conceive ideas, develop studies and derive conclusions as demonstrated by high profile publications. Excellent organizational, communication, and collaboration skills, with enthusiasm for working in a cross-functional environment.

Benefits

Discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.