Postdoctoral Associate

About the role

The Postdoctoral Associate will conduct NIH-funded research in the Aboudehen Laboratory within the Division of Nephrology and Hypertension, Department of Medicine. The laboratory studies RNA biology in autosomal dominant polycystic kidney disease (ADPKD) through two major research programs: (1) determining how disease-associated long noncoding RNAs regulate cyst initiation and progression, and (2) defining how RNA-binding proteins, RNA–RNA interactions, and other post-transcriptional mechanisms regulate PKD1 mRNA and polycystin-1 dosage. The lab uses complementary approaches in RNA biology, molecular and cellular biology, mouse genetics, and kidney-disease modeling to investigate ADPKD mechanisms and identify potential therapeutic targets. Research may involve genetically engineered mouse models of PKD, human kidney epithelial and primary ADPKD cells, and RNA-targeting technologies. The incumbent will conduct experiments, analyze and interpret data, prepare manuscripts and presentations, and ensure that all research is performed according to Stony Brook University policies and procedures.

The Research Foundation of SUNY is a private educational corporation. Employment is subject to the Research Foundation policies and procedures, sponsor guidelines and the availability of funding. FLSA Exempt position, not eligible for the overtime provisions of the FLSA. Minimum salary threshold must be met to maintain FLSA exemption. Visit The Office of Postdoctoral Affairs to learn more about our postdoctoral community.

Requirements

Doctoral Degree (or foreign equivalent) in RNA biology, molecular biology, cell biology, genetics, biochemistry, biomedical sciences or closely related field in hand by the start of the appointment.

Skills

• Research experience in RNA biology and post-transcriptional gene regulation
• Research experience in kidney biology or polycystic kidney disease
• Research experience in mouse genetics, transgenic mouse models, and animal phenotyping
• Research experience in mammalian cell culture, primary cells, or kidney organoids
• Research experience with RNA-targeting technologies such as siRNA and antisense oligonucleotides
• Experience with eCLIP, iCLIP, CLIP-seq, or related RNA–protein interaction assays (highly desirable)

Responsibilities

• Design and conduct molecular, cellular, and animal experiments investigating lncRNA function, PKD1 mRNA regulation, polycystin-1 biology, and ADPKD pathogenesis
• Studies may include genetically engineered mouse models, kidney phenotyping, mammalian cell culture, and primary ADPKD cells
• Collect, analyze, interpret, and document experimental data; perform literature searches; and apply specialized approaches in RNA biology, molecular biology, mouse genetics, and kidney-disease research
• Prepare manuscripts, scientific presentations, research reports, and grant-related materials
• Maintain mouse-colony and experimental records, laboratory materials, and equipment, and assist with ordering research supplies as needed
• Perform other duties as assigned, including attending scientific conferences, seminars, and meetings

Pay

$61,000-$72,000

Schedule

Full-time