Sr. Technical Program Manager, Infrastructure Engineering

Moderna is seeking a Senior Technical Program Manager (TPM) to drive project and program management of infrastructure (cloud and on-prem) rationalization and AI-readiness initiatives globally. We’re looking for someone with a high level of integrity, personal accountability, strong interpersonal skills, and infrastructure technology domain expertise.

Responsibilities

• Take a structured, data-driven, and risk-based approach to program scoping, execution, and reporting.
• Kick off and successfully manage multiple, simultaneous, complex, high-visibility workstreams with full ownership, effective collaboration, and good process.
• Build processes, templates, and structure, or leverage existing ones as appropriate.
• Manage vendors, schedule, scope, and cost.
• Measure program success (or lack thereof) and risks using data and facts.
• Provide balanced risk remediation strategies and recommendations and drive risk mitigation.
• Develop and maintain close stakeholder relationships and build influence to drive appropriate outcomes across Moderna.
• Provide clear, accurate, consistent, and timely communications.
• Advance good infrastructure and security practices and culture.
• Collaborate with Cloud Engineering, Systems Engineering, AI Engineering, Network Engineering, Identity and Access Management, Builder Tools & Platforms, IT, Cybersecurity, software engineering, and business stakeholders to manage and drive improvement projects in a structured and predictable manner.
• Manage multiple initiatives, including:
  • Cloud modernization.
  • Rationalizing infrastructure platforms, tooling, and service models that underpin AI workloads.
  • Identifying and eliminating redundant, unsupported, or non-scalable infrastructure patterns that impede AI adoption.
  • Enabling standardized, secure, and supportable “AI-ready” infrastructure foundations that accelerate time-to-value while managing cost and risk.
  • Ensuring infrastructure rationalization aligns with AI governance, data protection, and compliance requirements.
  • Defining and tracking KPIs related to platform consolidation, cost optimization, risk reduction, and AI enablement readiness.
  • Leading and driving infrastructure service management improvements and process optimization initiatives, including infrastructure patch and vulnerability management.
• Actively contribute to creating a more inclusive culture and environment at Moderna; endorse, create, and maintain antiracist policies and processes.

Requirements

• 8+ years of program management experience, preferably in infrastructure engineering.
• Demonstrated technical depth, problem-solving capabilities, and stakeholder and vendor management skills.
• Technical background in infrastructure engineering, with a strong understanding of ITSM.
• Experience running programs within a cross-functional, global team of mixed engineering, architecture, and operations.
• Ability to successfully scope and drive complex and multi-workstream programs in a structured, risk-considerate, data-driven fashion.
• Strong listener with the ability to deeply understand, ask the right questions, and proactively pursue constructive feedback.
• Proven ability to operate in highly matrixed environments and influence without direct authority.

Skills

• Strong understanding of cloud platforms (AWS, Azure).
• Familiarity with infrastructure concepts: compute, storage, networking, containers, Kubernetes.
• Working knowledge of AI/ML infrastructure needs (GPUs, distributed training, data pipelines, MLOps).
• Influential, inclusive, and trusted partner compassionate to the needs and situations of all stakeholders.
• Deep familiarity with ITSM frameworks (e.g., ITIL).
• Experience driving structured, process-driven infrastructure transformation initiatives.
• Knowledge of security and compliance standards relevant to infrastructure operations.
• Embrace a culture of continuous service improvement and service excellence.
• A desire to make an impact as part of a high-growth, transformational company.
• Experience with GxP environments and regulatory requirements.

Benefits

• Competitive healthcare, plus voluntary benefit programs to support unique needs.
• Holistic approach to well-being, with access to fitness, mindfulness, and mental health support.
• Family planning benefits, including fertility, adoption, and surrogacy support.
• Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown.
• Savings and investments to help plan for the future.
• Location-specific perks and extras.

Pay

The salary range for this role is $145,900.00 - $234,200.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An individual’s position within the salary range will be based on several factors including, but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, and business or organizational needs. The successful candidate may be eligible for an annual discretionary bonus, other incentive compensation, or equity award, subject to company plan eligibility criteria and individual performance.

Schedule

Moderna embraces a 70/30 work model, with 70% in-office structure to foster a culture rich in innovation, teamwork, and direct mentorship.