Sr. Associate Scientist, R&D Chemistry, Peptidomimetic Purification

About the role

We are currently seeking a lab-centric peptide purification chemist to join the R&D (Research & Development) Chemistry group. In this position, they will play a key role in Regeneron's peptidomimetic antibody-conjugate drug discovery capabilities to enable seamless combination with the company's existing expertise in biologics and novel genetic medicines. The candidate will drive the purification of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas.

Responsibilities

• Perform mass-triggered HPLC purification of novel peptidomimetic drug modalities, using modern purification instrumentation/detection and techniques
• Troubleshoot and optimize peptide purification methods and enable high throughput purification and isolation
• Identify new strategies and technologies for peptidomimetic purification to improve on existing Regeneron techniques
• Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic purification team
• Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations

Requirements

• Bachelor's degree required, Master's degree preferred in peptide, peptidomimetic, small molecule purification
• Minimum of 5 years of industry experience
• Extensive hands-on experience of the HPLC purification/detection and method troubleshooting of peptidomimetics
• Hands-on experience with Waters and/or Agilent purifications systems preferred
• Hands-on experience with mass-triggered collection preferred
• Experience with high throughput purification
• Extensive experience running modern purification/isolation equipment and instrumentation
• A track record of success in the field of either peptidomimetics or small molecules purification is required
• Working collaboratively with both internal and external organizations (e.g., CROs) is essential

Qualifications

• Passion and enthusiasm about the promise of peptidomimetic conjugated, antibody-targeted therapeutics and how peptide purification can enable their generation
• Comfortable working in a cross-functional role and excel in a diverse team where egos are checked at the door
• Willingness to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline
• Desire to work in an organization that is modality agnostic, letting the data determine the best course forward

Skills

• Strong communication and collaboration skills
• Ability to troubleshoot and optimize purification methods
• Knowledge of modern purification instrumentation and techniques
• Experience with high throughput purification

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Pay

$80,300.00 - $131,100.00 annually

Schedule

Full time