Senior Scientist, NGS Profiling & Expression

About the role

The Molecular Profiling Senior Scientist will work primarily with our research division's Discovery Oncology organization, providing targeted and NGS gene expression profiling support to reverse translation and preclinical target and biomarker validation efforts. Early discovery and pre-clinical work in support of other therapeutic areas will also be provided as needed.

Responsibilities

• Provide insight and guidance to cross-functional collaborators regarding experimental design for gene expression-based work
• Wet-lab support for project-based work including RNA isolation and gene expression profiling from bulk tissue, bulk sorted cell, and single cell populations
• Present and lead discussions on experimental results and data interpretation at team and/or department meetings
• Serve as Molecular Profiling representative to the Oncology translational research group as well as other program teams

Qualifications

• Education: Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. in biology, chemistry, biochemistry, molecular biology or related field and relevant experience
• Experience with molecular biology techniques, including RNA/DNA isolation and NGS library preparation
• Experience with targeted RT-qPCR and NGS platforms
• Experience with multi-omics NGS platforms, low cell number sorted populations, and/or single-cell RNAseq
• Prior experience in Oncology or Immunology
• Strong interpersonal skills with an ability to contribute effectively in a team-based environment
• Highly organized and able to manage time effectively
• Able to interface with translational, discovery, and clinical cross-functional colleagues to drive assay development and implementation into discovery and/or clinical programs as needed

Preferred Qualifications

• Experience with RNA/DNA QC platforms such as the Qubit, Fragment Analyzer, Agilent Bioanalyzer or Tapestation
• Experience with liquid automation for sample RNA/DNA isolation and NGS library prep
• Experience with NGS analysis data visualization software such as Cell Ranger, Partek, OmniBrowser, or BioTuring
• Familiarity with computer software: Illumina BaseSpace, Illumina Dragen, Spotfire, Graphpad Prism, Ingenuity Pathway Analysis
• With management guidance, ability to incorporate innovative scientific and technical advances to support Profiling & Expression priorities

Requirements

• Current Employees apply HERE
• Current Contingent Workers apply HERE

Benefits

• Medical, dental, vision healthcare and other insurance benefits (for employee and family)
• Retirement benefits, including 401(k)
• Paid holidays, vacation, and compassionate and sick days

Pay

$131,400.00 - $206,800.00

Schedule

Shift 1st - Day