Senior NGS Bioinformatician

About the role

We are seeking a Senior NGS Bioinformatician to join our Bioinformatic Product Development team. This role is a hybrid opportunity, requiring 3 days onsite our corporate office in Rolle, CH or Boston, MA.

Responsibilities

• Explore novel technologies, biological questions, and new analytical approaches
• Design and analyze analytical performance studies supporting IVD/CDx and biopharma projects
• Lead data exploration efforts to address practical questions that arise during product development
• Evaluate and improve algorithmic performance across variant classes and technologies
• Conduct deep-dive analyses to generate biological insights from complex datasets
• Contribute to performance evaluation documentation supporting IVD/CDx development
• Contribute code to production-grade NGS pipelines, ensuring robustness, reproducibility, and performance
• Contribute to scientific publications, white papers, or conference presentations
• Contribute to projects with external collaborators, including project planning, data analysis, and results presentation

Requirements

• PhD in Bioinformatics / Computational Biology (or equivalent industry experience)
• 5+ years of experience in NGS data analysis in academic, biotech, or diagnostics environments
• Experience analyzing somatic variants (SNVs, indels, CNVs, fusions) in oncology NGS assays
• Experience with targeted panel sequencing and/or hybrid capture technologies
• Strong proficiency in Python and/or R for statistical analysis and data exploration
• Experience working with workflow management systems (e.g., Nextflow or similar) is highly desirable
• Excellent communication & presentation skills (English is a must, any other language is an asset)
• Strongly valued experience: Hematologic cancer biology, RNA/transcriptomic analysis, In vitro diagnostic development, Analytical performance study design and statistical analyses

Benefits

• Sickness and Accident coverage through Helsana
• Meal Vouchers at 90CHF PM with our partner cafeteria
• A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit
• Free parking in an easy to access location
• A strong social committee whose purpose is to make SOPHiA GENETICS both enjoyable as well as rewarding

Pay

USD 71'250-143'750