Senior Scientist, In Vivo Pharmacology, Inflammation Research (Respiratory Focus)

Key Responsibilities

• Lead and perform hands-on in vivo work and run concurrent studies mice/possibly rats
• Serve as manager with at least two direct reports Scientist and Associate Scientists
• Design experiments, oversee study execution, and ensure studies are completed on schedule
• Act as in vivo PTR on project teams: represent and communicate in vivo data to project teams and department
• Mentor, support, and manage direct reports performance, development, supervision
• Maintain organization, attention to detail, and study preparation
• Participate in panels/seminars as part of interview/hiring and in broader scientific communication as needed
• Participate in weekend/evenings dosing rotations when required.

Basic Qualifications

• Doctorate degree PhD
• OR PharmD
• OR MD and Immunology experience
• OR Masters degree and 3 years of f Immunology or related experience
• OR Bachelors degree and 5 years of f Immunology or related experience

Preferred Qualifications

• Willingness and curiosity to learn and explore new areas of research
• Significant experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t.,i.d.,s.c.), respiratory virus infection (PR8)
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC important
• Significant hands-on expertise in animal (mouse and rat) handling and in vivo techniques (i.v.,i.p.,p.o.,i.d.,s.c., i.t., bleeds, necropsy)
• Significant experience with lung function measurements (FlexiVent, Plethysmography), imaging (mCT), and inhaled drug delivery
• Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, quantitative RT-PCR, BCA protein measurements)
• Hands-on experience with multicolor flow cytometry including Spectral flow approaches and Immune cell populations is essential
• Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word
• Attention to detail, excellent organizational and communication skills, accurate & timely record keeping and data analysis are essential
• Demonstrated track record of independent critical thinking and scientific achievement
• Demonstrated experience in and understanding of pharmacology with application using in vivo models of inflammation/Immunology
• Experience working on project teams leading in vivo contributions
• Experience managing an in vivo pharmacology team or direct reports (2 years)
• Ability to work in a flexible team-oriented environment. Weekend and evening work may be required.