Senior Scientist, In Vitro and In Vivo Pharmacology

Responsibilities

• Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development programs.
• Develop mechanistic assays evaluating target engagement, receptor occupancy, signaling pathways, cytokine modulation, immune cell activation, and pharmacodynamic responses.
• Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
• Generate data packages that support candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
• Identify emerging targets and pathways associated with protease driven and immune-mediated disease.
• Serve as a scientific representative on project teams, contributing to research strategy, development plans, and decision-making.
• Collaborate with external CROs, academic investigators, and clinical collaborators.
• Present scientific findings to senior leadership and project governance teams.
• Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.

Qualifications

• PhD in Pharmacology, Immunology, Cell Biology, Molecular Biology, Biomedical Sciences, or related discipline.
• Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
• Demonstrated experience supporting discovery and translational development of biologic therapeutics.
• Experience working within cross-functional drug development teams from early research through clinical development.