Scientist, In Vivo Pharmacology, Inflammation Research

Key Responsibilities

• Perform hands-on in vivo work primarily mice, possibly rats and run concurrent studies
• Design experiments and execute studies, working alongside senior scientists and associate scientists
• Generate high-quality experimental data and ensure studies are organized and prepared
• Supervise/coordinate associate scientists tasks/time as needed for study execution.
• Analyze and communicate results to project teams and the broader department
• Understand the biology of supported projects and contribute to project progression
• Participate in occasional weekend/evening dosing rotations as required.

Qualifications

• Doctorate degree
• OR Masters degree and 2 years of Immunology or related experience
• OR Bachelors degree and 4 years of Immunology or related experience
• Strong understanding of Immunology and Inflammation biology and principles
• Willingness and curiosity to learn and explore new areas of research
• Experience executing in vivo preclinical respiratory disease models, including asthma (OVA, HDM), COPD (Elastase, smoke extract), Bleomycin fibrosis (i.t.,i.d.,s.c.), respiratory virus infection (PR8) models preferred
• Experience with preclinical inflammatory disease models, including colitis, lupus, RA, PBC important
• Significant Experience with lung function measurements (FlexiVent, Plethysmography), imaging (mCT), and inhaled drug delivery preferred
• Hands-on experience with in vivo techniques including dosing route of administration (i.v.,i.p.,p.o.,i.n., i.t.,r.o.,i.d.,s.c.), bleeds (r.o., cheek, tail), necropsy (organ collection (intestine/colon, lung,lymphnodes, spleen, liver, kidney, skin), cardiac bleed, lung BAL collection)
• Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi-color flow cytometry, quantitative RT-PCR) preferred
• Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word
• Attention to detail, excellent organizational and communication skills, accurate & timely recordkeeping and data analysis are essential
• Demonstrated track record of independent critical thinking and scientific achievement
• Demonstrated experience in and understanding of pharmacology with application using in vivo models of inflammation/Immunology
• Experience working on project teams leading in vivo contributions
• Ability to work in a flexible team-oriented environment. Weekend and evening work may be required.