Scientist I, In Vivo Pharmacology

About the role

The expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives.

Core Responsibilities

• Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
• Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies
• Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
• Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets
• Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals
• Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques
• Appetite for developing novel in vivo approaches and models to address complex biological questions

Requirements

• BS with 5+ years of experience or MS 2+ years with a degree in physiology, pharmacology, molecular biology or any related field of biology is required
• Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation (subcutaneous, disseminated etc.), tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection
• Familiarity with huPBMC and CD34 humanized mice is highly desired
• Experience with mouse models of cancer, including CDX and/or PDX xenograft models is preferred
• Familiarity with data analysis, presentation, data management, and statistical software (e.g. Microsoft Office, Study Director, GraphPad Prism) is a plus
• Grounding in ADC or TCE therapeutics is desired

Key Leadership Competencies

• Buils strong relationships with peers and cross-functionally with partners outside the team to enable higher performance
• Learns quickly and changes course when indicated
• Raises the bar and is never satisfied with the status quo
• Embraces others' ideas, nurtures innovation and brings it to reality

Pay

$75,000 - $142,500 USD

Where We Work

This role is exclusively performed at a site or office and onsite presence is required. Employees who are site/office-based and can occasionally perform their role virtually work both in the office and remotely*, following the policies and regulations in place at their location. US Employees must be in the office on Tuesday, Wednesday, and Thursday with flexibility to work remotely on Mondays and Fridays. Three days in the office is the minimum; some individuals or teams may require more in-office days due to meetings, business/project needs or their role.