Scientist I, In Vivo Pharmacology

About the role

The In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist to discover and develop innovative small-molecule and biologic therapeutics. The position focuses on tumor-targeting biologics including ADCs and T-cell engagers (TCE) therapeutics in both immunocompromised and humanized mouse models. The successful candidate will work closely with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline.

Responsibilities

• Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
• Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies
• Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
• Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets
• Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals
• Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques
• Appetite for developing novel in vivo approaches and models to address complex biological questions

Qualifications

• BS with 5+ years of experience or MS 2+ years with a degree in physiology, pharmacology, molecular biology or any related field of biology is required
• Strong technical expertise in in vivo experimentation, including health monitoring, tumor implantation (subcutaneous, disseminated etc.), tumor measurements, dosing via IP, IV, SC, PO routes, and blood/tissue collection
• Familiarity with huPBMC and CD34 humanized mice is highly desired
• Experience with mouse models of cancer, including CDX and/or PDX xenograft models is preferred
• Familiarity with data analysis, presentation, data management, and statistical software (e.g. Microsoft Office, Study Director, GraphPad Prism) is a plus
• Grounding in ADC or TCE therapeutics is desired

Key Leadership Competencies

• Buils strong relationships with peers and cross-functionally with partners outside the team to enable higher performance
• Learns quickly and changes course when indicated
• Raises the bar and is never satisfied with the status quo
• Embraces others' ideas, nurtures innovation and brings it to reality