Senior Scientist, In-vivo CAR-T

Purpose

The Senior Scientist will support the development, optimization, and scale-up of lentiviral vector (LVV) drug product processes from early to late-stage development. The role combines hands-on laboratory work with strong cross-functional collaboration to ensure robust, scalable, and GMP-ready processes.

Key Responsibilities

• Design and execute LVV process development studies across early and late development stages
• Collaborate with modelling experts, data scientists to identify opportunities where modelling or machine learning can reduce experimental burden, improve robustness, or define process design space
• Perform hands-on laboratory work including process design, optimization, and characterization
• Analyze and interpret data to support process understanding, optimization, and decision-making
• Support process characterization activities, including identification of CPPs and development of robust processes
• Contribute to scale-up and manufacturing readiness, including support of technology transfer to internal sites or CMOs
• Collaborate cross-functionally with Analytical Development, MSAT, Quality, Manufacturing, and Regulatory teams to ensure alignment on process strategy and execution
• Document experimental work and results in accordance with GxP and data integrity requirements
• Participate in troubleshooting activities and continuous process improvement initiatives

Qualifications

• Ph.D. 0-2 years' experience, B.S. or M.S. with 4-6 years' experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering) is required
• Relevant experience in process development of viral vectors and/or LVV formulation development
• Strong hands-on laboratory experience in drug product or viral vector development
• Understanding of process scale-up, technology transfer, and GxP principles
• Strong scientific problem-solving and data interpretation skills
• Hands-on, proactive, and detail-oriented approach
• Ability to work effectively in a cross-functional, matrixed environment
• Clear and concise communication skills (written and verbal)
• Ability to manage multiple priorities in a dynamic development environment

Preferred Experience

• Experience with LVV platforms, viral vectors and/or advanced therapies
• Familiarity with process validation (e.g., LCPV) and manufacturing support
• Exposure to both early and late-stage development or commercial readiness activities