Scientist / Senior Scientist, In Vivo CAR-T

About the Role

Addition Therapeutics is seeking a highly skilled and motivated Scientist / Senior Scientist to join the Preclinical Translation team and lead the design and hands-on execution of in vivo CAR-T studies. This role emphasizes experimental execution, animal handling, model development, and data interpretation. The ideal candidate will work closely with scientists across Preclinical, Disease Biology, CMC, and Discovery functions to generate and integrate in vivo efficacy and cellular/molecular readouts to advance CAR-T programs.

Responsibilities

• Develop and optimize in vivo models to evaluate CAR-T efficacy, tumor killing, expansion, persistence, and activity.
• Design and execute in vivo CAR-T studies in appropriate humanized mouse models.
• Perform animal handling and procedures, including dosing, blood collection, tissue and tumor harvest, and sample processing for downstream analyses.
• Perform and interpret multiparameter flow cytometry analyses to characterize CAR-T cells and immune populations.
• Support molecular and protein-based analyses, as needed.
• Integrate in vivo efficacy, cellular, and molecular readouts to guide program decisions.
• Develop study protocols and contribute to IACUC amendments, animal welfare, compliance, and study documentation.
• Manage external studies with CROs, including vendor selection, protocol design, oversight, and data review, analysis, and interpretation.
• Troubleshoot experimental challenges and drive improvements in study execution and model performance.
• Maintain detailed and organized study records; contribute to study reports and presentations.

Qualifications

• PhD in Biology, Pharmacology, Immunology, Cancer Biology, or related field, with 4-6 years of relevant research or industry experience.
• Demonstrated hands-on in vivo pharmacology experience, including animal handling, dosing, tissue collection, and necropsy.
• Experience with CAR-T in vivo models, preferably humanized mice and tumor models.
• Experience assessing in vivo tumor killing/efficacy and CAR-T expansion or persistence.
• Proficiency with flow cytometry and data analysis.
• Experience managing in vivo studies at CROs.
• Experience with ddPCR, ELISA/MSD, or related molecular/protein assays is preferred.
• Strong experimental, analytical, troubleshooting, organizational, and communication skills.
• Meticulous attention to detail and strong documentation including use of electronic notebook for record keeping.
• Team player who fosters a culture of collaboration, accountability, and scientific excellence, and who thrives in a fast-moving, results-oriented startup environment.
• A self-motivated, driven individual with a passion to learn and can-do attitude.

Pay

The expected yearly salary for this position is $116,000-$166,000. Exact compensation may vary based on skills and experience.

Location

South San Francisco, California