Senior Scientist, Drug Discovery Biochemistry & Biophysics

About the role

We're seeking a driven and highly skilled Senior Scientist to build and execute our protein biochemistry, biophysics, and drug discovery assay capabilities. In this role, you will:

• Design, express, purify, and characterize recombinant proteins to support biochemical, biophysical, target engagement, and structural studies.
• Develop construct, tag, truncation, mutation, and purification strategies, and apply analytical methods (SEC, SDS-PAGE, activity, LC-MS, DLS, thermal shift etc.) to assess protein purity, identity, oligomeric state, stability, and assay suitability.
• Develop, validate, and run biochemical and biophysical assays (FR, TR-FRET, AlphaScreen/AlphaLISA, DSF, enzymatic, SPR, BLI) to support hit validation, SAR, selectivity, mechanism of action, and lead optimization.
• Generate quantitative data on affinity, potency, kinetics, residence time, reversibility, competition, allostery, selectivity, and design orthogonal assays.
• Partner with medicinal chemistry to interpret SAR, prioritize compounds, and shape assay strategy.
• Build focused cell-based assays that connect biochemical /biophysical target engagement to cellular pharmacology, covering target engagement, pathway modulation, biomarker response, potency, selectivity and counterscreens.
• Develop fit-for-purpose readouts (e.g. high content cell imaging, qPCR, reporter, viability) for SAR and mechanism.

Requirements

You have:

• A PhD in biochemistry, biophysics, chemical biology, structural biology, pharmacology, cell biology, or a closely related field.
• 3–5 years of industry experience in small molecule drug discovery, developing biochemical, biophysical, and/or cellular assays.
• Hands-on experience in recombinant protein expression, purification, and analytical characterization, independently generating high-quality reagents for quantitative assays.
• A strong grasp of assay development principles, (robustness, reproducibility, dynamic range, signal-to-background, Z', CV etc.).
• Bonus points for experience with structural biology methods such as NMR, X-ray crystallography, or cryo-EM.
• Familiarity with aging biology, senescence, mitochondrial function, proteostasis, inflammatory signaling, metabolic pathways, or other age-related disease biology.
• Experience leveraging AI and coding agents in the context of drug discovery, computational chemistry, and leveraging large-scale biological datasets to augment drug discovery.

Qualifications

You have:

• Strong communication skills to collaborate effectively with cross-functional teams.
• Ability to manage multiple projects simultaneously and meet deadlines.
• Excellent problem-solving and troubleshooting skills.
• Proficiency in relevant software tools and techniques.