Senior Scientist, Discovery Chemistry

The Importance of the Role

The RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced discovery chemistry team located in Bedford, MA.

This position will work closely with Discovery Biology, Translational Sciences, Research Operations, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics.

The Opportunity to Make a Difference

• Design and conduct novel oligonucleotide conjugates synthesis, purification, and characterization;
• Apply state-of-the-art delivery methods to achieve in vivo proof of concept;
• Develop efficient and scalable synthetic methods and routes;
• Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships;
• Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data;
• Serve as an in-house oligonucleotide and delivery chemistry expert;
• Drive the writing of technical reports to support patent applications and manuscript preparations;
• Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs;
• Organize workstreams and complete individual and team objectives to maintain project timelines;
• Supervise and mentor junior staff.

About You

• The ideal candidate will have a PhD in organic chemistry, biochemistry, or related fields with 5+ years of relevant post-doctoral or industry experience.
• Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.
• Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.
• Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.
• Hands‑on experience in computational chemistry, including CADD, structure‑based design, ligand‑based modeling, or other predictive computational frameworks, is strongly preferred.
• Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.
• Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.

What Now?

We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.

This position requires work on site at one of Sarepta’s facilities in the United States.

The targeted salary range for this position is $112,000 - $140,000 per year.

Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.