Senior Researcher in Protein Technologies Center

About the role

The Senior Researcher will participate in the Blue Sky Initiative “Seeing the Invisible in Protein Kinases” at St. Jude Children's Research Hospital. This initiative is an inter-disciplinary project in the Department of Structural Biology, supported by US $50 million in institutional funding. The goal is to characterize the conformational landscape of the human kinome using advanced techniques like ultra-high field nuclear magnetic resonance (NMR), cryoEM, X-ray crystallography, and data-science. The researcher will study the molecular mechanisms and structures of protein kinases, their cellular regulatory functions, and discover new biology related to kinase function and regulation.

Responsibilities

• Use molecular biology, biochemistry, and biophysical skills to study the molecular mechanisms and structures of protein kinases.
• Assist in preparing high-quality proteins from various expression systems (bacteria, insect cells, and mammalian cells) for structural studies of kinases using NMR, crystallography, and cryo-EM.
• Contribute to the discovery of new mechanisms of kinase regulation and kinase-mediated biology through biophysical and structural studies.

Requirements

Minimum Education and/or Training: Bachelor’s degree in relevant scientific area is required. Minimum Experience: Two (2) years of research experience is required with a bachelor's degree. No prior experience is required with a Master’s degree.

Working knowledge and understanding of underlying concepts and principles of experimental design. Experience with the most widely used techniques used in the home laboratory. Proven performance in earlier role/comparable role.

Qualifications

Proven success in designing and executing experiments. Strong communication and teamwork skills. Ability to work independently and as part of a multidisciplinary team.

Skills

• Experience with molecular biology techniques.
• Knowledge of biochemistry and biophysical methods.
• Understanding of structural biology and protein engineering.
• Ability to work with complex datasets and perform data analysis.

Benefits

St. Jude Children's Research Hospital offers a remarkable opportunity to perform cutting-edge research with outstanding institutional support and exceptional shared core facilities. The hospital is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child.

Pay

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $26.00 - $45.50 per hour for the role of Senior Researcher in Protein Technologies Center.

Schedule

Full-time position.