Senior Scientist, Computational Protein Engineering

Position Summary

This position is responsible for planning and developing an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company.

Duties And Responsibilities

• Independently designs and develops an in-silico platform for antibody and other protein engineering in collaboration with other scientists in the group and across the company
• Develops computational pipelines for protein structure determination using structural and/or sequence-based methods and/or artificial intelligence methods (e.g. Rosetta, AlphaFold)
• Develops computational pipelines for protein docking and antibody epitope mapping
• Independently combines data from different sources and analyzes these or incorporates these into multidimensional optimization of protein interactions
• Leads a technical team to implement computational pipelines in protein design, engineering, or prediction
• Critically evaluates experimental data and incorporates this knowledge into design
• Provides input to the management team to identify, develop, and execute departmental initiatives and strategies
• Leads technical team(s) to accomplish project goals and manages/coordinates work of other team members
• Presents findings/analyses and any associated issues/solutions to peer groups and managers; make recommendations for project advancement
• Leads cross-functional initiatives with other business units on projects/products or associated deliverables
• Establishes and monitors direct report performance and development goals, assigns accountabilities, sets objectives, establishes priorities, and provides continuous coaching and recognition on performance
• Stays current technological developments in area of expertise, expands knowledge through independent learning
• Maintains organized, detailed and clear project records for self and direct reports
• Understands, follows and enforces laboratory safety precautions to ensure compliance with company safety policies

Experience And Qualifications

• PhD in structural bioinformatics, molecular biology, bioengineering, biophysics, computational biology, or related field with 2 years of relevant experience
• Expertise with protein and antibody modeling, including antigen-antibody interactions
• Publications in the form of high-profile papers/patents within protein prediction or de novo protein design, including antibody or enzyme engineering
• Experience with artificial intelligence and/or machine learning methods is desirable

Experience And Qualifications

• Proven record of remaining current, learning new techniques/research in areas of computational biochemistry
• Superior scientific fundamentals and analytical background
• Ability to work independently and in teams, and to collaborate with external parties
• Excellent communication skills and the ability to work in a highly dynamic and collaborative environment
• Expert problem solving skills and demonstrated ability to organize and move project tasks forward in an orderly and structured fashion
• Strong analytical skills with the demonstrated ability to gather and evaluate complex data and information and develop a recommendation and plan of action
• Excellent organizational, planning, and time management skills required, with the ability to manage multiple and often changing priorities and issues of varying complexity while meeting time-sensitive deadlines and deliverables
• Strong leadership skills with demonstrated knowledge and understanding of staff management practices and processes
• Ability to establish accountabilities and expectations and manage performance to achieve results
• Demonstrated propensity to be creative, collaborative, proactive, and self-motivated in the execution and completion of assigned tasks
• Exceptional communication (written and verbal) skills regardless of the format (e.g., documents, public speaking situations, presentations, etc.)
• Project-level understanding and attention to detail with demonstrated commitment to excellence and performance
• Proven proficiency with Microsoft Office (i.e., Word, Excel, PowerPoint, Outlook)

Physical Demands

• While performing the duties of this job, the individual is frequently required to sit and stand for long periods. The individual is occasionally required to walk; use hands and fingers to operate, handle, or feel objects, tools, or controls; reach with hands and arms.
• Up to 10% of the day may be spent at a laboratory bench. There are aspects of the position’s duties that require a person in this role to work at heights above four (4) feet on occasion and move/lift up to 25 pounds.