Senior Research Technician - Pediatrics Cardiology

Location: St. Louis, MO 63110 | Scheduled Hours: 40

About the Role

Our laboratory is dedicated to advancing the understanding of vascular biology, with a particular emphasis on the mechanisms that drive vascular dysfunction and remodeling in disease. A central focus of our work is hypoxia-induced pulmonary hypertension, a devastating condition characterized by maladaptive changes in the pulmonary vasculature that culminate in elevated pressures and right heart failure. We investigate how low oxygen tension alters cellular signaling and vascular homeostasis, leading to activation, injury, and reprogramming of key vascular cell types, including endothelial cells, smooth muscle cells, pericytes, and fibroblasts. By mapping the molecular interactions and signaling networks that govern these processes, we aim to uncover the drivers of pathological remodeling.

In parallel, we are interested in the regenerative capacity of vascular tissues and the potential for cellular reprogramming to restore function. This includes dissecting pathways of vascular regeneration, repair, and plasticity that could be harnessed to reverse damage. Our integrated approach spans molecular, cellular, and in vivo systems to bridge fundamental biology with translational discovery. Ultimately, the goal of our research is not only to illuminate the underpinnings of vascular pathology but also to exploit these insights for the development of novel therapeutic strategies. By targeting maladaptive signaling and promoting regenerative programs, we strive to pioneer innovative treatments for pulmonary hypertension and other vascular diseases.

Responsibilities

• Performs complex analysis, projects, research studies, experiments, and assays according to research protocols, explaining methods and procedures to other technicians.
• Enters data and maintains current data files on research projects. Monitors data to ensure consistent quality.
• May perform preliminary statistical analysis of data.
• Assures compliance with established safety procedures and maintains required documentation on laboratory and specimen conditions.
• Ensures lab conditions and equipment are properly cleaned and maintained in accordance with established procedures.
• Assists in the training and development of technicians, acting as a group leader.
• Performs other duties as assigned.

Working Conditions

• Works in a laboratory environment with potential exposure to biological and chemical hazards.
• Must be physically able to wear protective equipment and to provide standard care to research animals.

Requirements

• Master’s degree or combination of education and/or experience may substitute for minimum education.
• 1 year of experience in a laboratory setting.

Preferred Qualifications

• Experience working with small animals.

Skills

• Communication
• Laboratory Instrumentation
• Recordkeeping
• Software Program
• Working Independently

Pay

Salary Range: $18.77 - $31.94 / Hourly

Benefits

• Up to 22 days of vacation, 10 recognized holidays, and sick time.
• Competitive health insurance packages with priority appointments and lower copays/coinsurance.
• Free Metro transit U-Pass for eligible employees.
• Defined contribution (403(b)) Retirement Savings Plan, combining employee contributions and university contributions starting at 7%.
• Wellness challenges, annual health screenings, mental health resources, mindfulness programs, employee assistance program (EAP), financial resources, and access to dietitians.
• 4 weeks of caregiver leave to bond with a new child, plus family care resources for childcare and adult care needs.
• Tuition coverage for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years.