Senior Principal Scientist - Bioanalytical Sciences

About the role

The Assay Development Group (ADG) in Bioanalytical Sciences, located in Tarrytown, NY, is seeking a Senior Principal Scientist to join their team.

Responsibilities

• Create and execute novel assay strategies for all biotherapeutic modalities, designing experiments, troubleshooting problems, organizing and interpreting experimental results and performing follow-up experiments.
• Supervise a team of scientists in the development and validation of immunoassays for the measurement of drug, drug complexes and anti-drug antibodies to support new programs.
• Guide the designs and execution of immunoassays (PK, PD and ADA) by direct reports, based on protocols provided by literature, seminars and other scientists. Suggest troubleshooting experiments for assay-related problems, follow-up experiments to further assay development and optimize assays.
• Routinely reviews data for multiple developmental projects, working on these projects simultaneously. Summarizes and presents results internally to management and externally in industry meetings.
• Writes/reviews assay validation protocols, reports and SOPs prior to submission to Quality Auditing (QA).
• Functions as Study Director for assay validation studies conducted by direct reports.

Requirements

• A PhD degree with 5+ years meaningful experience, or a MS with 8+ years meaningful experience, or a BS with 10+ years meaningful experience.
• An in-depth understanding of the science and technology on the development and validation of immunoassays.
• The ability to perform sophisticated technical tasks to pursue projects that incorporate a diverse set of skills and work on multiple projects/experiments simultaneously.

Qualifications

• PhD in Biochemistry, Molecular Biology, Biotechnology, Chemistry, Immunology, or related field.
• Experience in developing and validating immunoassays for biotherapeutics.
• Proven track record of leading and mentoring a team of scientists.
• Strong communication and interpersonal skills.
• Ability to work independently and manage multiple projects simultaneously.

Skills

• Expertise in immunoassay development and validation.
• Knowledge of biotherapeutic modalities including monoclonal antibodies, bispecifics, ADCs, AAV, CAR-T, RNA, and drug target biomarkers.
• Experience in PK, PD, and ADA assays.
• Strong problem-solving and troubleshooting skills.
• Excellent organizational and project management skills.

Benefits

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

Pay

$150,500.00 - $245,500.00 annually

Schedule

Full-time