Senior Manager, Clinical Project Management (Project Delivery)

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets.

About the role

The Senior Manager, Clinical Project Management (Clinical Project Delivery CPD) provides hands-on operational management for the execution of one or more of Immunome’s clinical trials, supporting all aspects of cross-functional clinical trial delivery from planning and initiation through completion to ensure studies are executed on time, within budget, and in compliance with regulatory requirements and corporate objectives. The Senior Manager acts as the primary point of accountability for study-level timelines, enrollment projections, budgets, and vendor performance for assigned trials. The Senior Manager may support one or more studies and/or development programs under the guidance of an Associate Director or above.

Responsibilities

• Clinical Project Delivery: Lead cross-functional facilitation of clinical study teams through the trial lifecycle. Own study-level timeline development, tracking, and reporting for assigned trials. Develop and maintain enrollment graphs and dashboards, ensuring accuracy and timely updates to inform decision-making. Monitor project delivery metrics (timelines, milestones, enrollment, budget adherence, vendor KPIs) and ensure corrective action when studies are at risk. Facilitate or support cross-functional planning, execution, and delivery of assigned clinical trials on time, within budget, and to quality standards. Help the clinical study team (CST) identify operational risks and implement mitigation strategies to ensure successful trial delivery.
• Clinical Operations: Champion a culture of accountability, collaboration, and continuous improvement. May contribute to functional and/or departmental initiatives. May mentor new or junior team members.
• Vendor Management: Manage CRO and Central lab relationships and