Senior Director, Commercial Development

About the role

The Senior Director, Commercial Development will play a pivotal role in shaping the future of Madrigal. Reporting to the Head of Global Marketing and Commercial, this individual will be responsible for driving portfolio strategy and representing the global commercial perspective across Madrigal’s pipeline. This role requires a deep understanding of specialty pharma market dynamics, competitive intelligence, and commercial strategy.

Responsibilities

• Shape commercial perspective on indication prioritization, endpoints, comparator strategy, and trial design.
• Identify label-optimizing opportunities and evidence needs to support global approval, access, and adoption.
• Lead early readiness planning for new product and indication launches.
• Support cross-functional commercialization planning with Sales, Marketing, Market Access, Patient Access, Thought Leadership, Communications, and Medical Affairs for coordinated launch readiness and market shaping.
• Collaborate on revenue forecasting, scenario planning, and pricing/market uptake assumptions.
• Inform investment, launch sequencing, and lifecycle decisions with commercial assessments.
• Provide strategic guidance on target product profiles (TPP), market positioning, clinical development prioritization, and commercial readiness to maximize portfolio value.

Requirements

• Proactive, self-starter with a business owner mindset.
• Strategic thinker with strong commercial acumen and ability to balance near-term development priorities with long-term asset value.
• High learning agility and problem-solving skills with the ability to multi-task across several projects.
• Data-driven decision maker with strong analytical skills to quickly diagnose problems and develop fit-for-purpose solutions.
• Ability to influence without formal authority to drive cross-functional alignment.
• Superb communication skills, both verbal and written.
• Desire to professionally develop and gain more responsibilities resulting in greater impact.

Skills

• Deep and direct commercial development experience (5+ years) advancing multiple pre-commercial assets to launch.
• Experience with MASH or related therapeutic areas.
• Strong scientific background.
• Experience in smaller company (or team) environments.