Senior Associate Scientist, AAV Cell Line Development (Contractor)

About the role

The ideal candidate will have a proven track record performing AAV and/or lentiviral vector stable producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for AAV and/or lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams.

Responsibilities

• Perform AAV and/or lentiviral vector stable producer cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment
• Support innovation through development of novel workflows and applications
• Support research projects to develop viral vector therapeutics with enhanced quality attributes such as empty/full ratio, potency and/or cell targeting
• Design experiments, analyze data, troubleshoot, and maintain detailed records
• Represent the cell line development function on project teams, making decisions for cell line activities and effectively communicating results, progress and plans

Requirements

• B.S or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field
• 5+ years of hands-on experience in AAV and/or lentiviral vector producer cell line development in support of GMP production of cell or gene therapies
• Experience performing transfections, viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR, qPCR, ELISA) is highly desired
• Experience with viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired

Qualifications

• Strong written and verbal communication skills are required

Skills

• Hands-on experience in AAV and/or lentiviral vector producer cell line development
• Experience with state-of-the-art equipment for cell line development
• Knowledge of viral genome engineering and host cell genome engineering
• Experience with ddPCR, ELISA, and flow cytometry
• Ability to design and troubleshoot experiments
• Effective communication skills

Benefits

This is a full-time, 6-month contract position providing maternity leave coverage. While the role is intended to support this temporary need, there may be an opportunity to extend the contract or transition to a permanent position based on business needs.

Pay

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Schedule

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Benefits

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