Scientist, RNA Chemistry

Primary Responsibilities

• Independently perform synthesis of modified RNA oligonucleotides (ASO, siRNAs) incorporating diverse sugar and backbone chemistries at scales suitable for both in vitro and in vivo studies.
• Troubleshoot and optimize synthesis methods to produce high quality oligonucleotides of various lengths.
• Interpretation of analytical data (HPLC, LCMS) to enable improved purity and yields of synthesized oligonucleotides.
• Carry out purification (anion exchange, reverse phase), analysis (IP/RP, IEX, SEC), characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates.
• Register synthesized oligonucleotides in the database (sequence, lot, and QC) and precisely report experiments in the ELN.
• Contribute to the design of oligonucleotides against various targets and rationally perform the hit-to-lead optimization process.
• Generate intermediates to prepare antibody-oligonucleotide conjugates.
• Cross-functional collaboration to define deliverables and timelines.
• Multi-task across several projects and manage time effectively to achieve results.
• Perform lab maintenance activities in collaboration with peer scientists and lab operations.
• Collect, present, and discuss data at internal team meetings.

Education And Skills Requirements

• PhD in Chemistry or a related scientific discipline with 2 years of experience, or MSc with a minimum of 8 years of relevant industry experience in biotechnology or life sciences.
• Postdoctoral experience is a plus.
• Hands-on experience operating oligonucleotide synthesis and purification platforms, including MerMade, K&A, and AKTA Oligopilot.
• Experience with oligonucleotide conjugation, including antibody conjugation, is a plus.
• Familiarity with biochemical and analytical assays used to assess stability, properties, and mechanism of action of modified RNA oligonucleotides.
• Independently executes experimental work within defined research projects, applying sound scientific methodology to address increasingly complex problems.
• Interprets and communicates experimental data to support program advancement and decision-making.
• Demonstrates strong cross-functional collaboration skills, working effectively with internal partners to advance shared scientific objectives.

Pay Range

MA Pay Range $118,000 - $145,000 USD